高频下降型突发性耳聋的临床危险因素及其与预后的相关性

Analysis of clinical risk factors for high frequency descending sudden deafness and their correlation with prognosis

目的:分析高频下降型突发性耳聋的危险因素及其与预后的关系。方法:回顾性分析2017年1月至2019年1月期间于我院耳鼻喉科住院诊治的高频下降型突发性耳聋患者125例(实验组)以及非耳聋的住院患者125例(对照组)。分别检测两组患者的血脂、凝血功能和血常规,收集所有研究对象的相关临床资料,并分析各指标与高频下降型突发性耳聋患者疗效之间的相关性。结果:实验组和对照组中血脂指标(TC、TG、LPa、HDL-C、LDL-C)、凝血指标(APTT)、血常规指标(NEUT)差异具有统计学意义(P<0. 05),而游离脂肪酸(NEFA)、凝血指标(FIB、PT)、血常规指标(PLT、WBC)在两组中差异无统计学意义(P>0. 05)。另外,TC、APTT、年龄、伴有眩晕、听力损失程度、就诊时间与疗效具有显著的相关性(P<0. 05)。结论:高频下降型突发性耳聋患者中血脂指标(TC、TG、LPa、LDL-C)、凝血指标(APTT)、血常规指标(NEUT)较高,HDL-C指标较低,高水平TC和APTT、年龄大于50岁、伴有眩晕、听力损失程度较重、就诊时间较晚的高频下降型突聋患者的预后差。

Objective: To analyze the risk factors of high-frequency descending sudden deafness and their relationship with prognosis.Methods: We retrospectively analyzed the 125 cases of high-frequency descending sudden deafness(experimental group) and the 125 cases of non-deafness(control group), all patients were in the Department of Otolaryngology, from January 2017 to January 2019 of Zhongnan Hospital of Wuhan University. Routine blood, blood coagulation function and blood lipids were detected, and relevant clinical datas were collected to analyze the correlation between each index and the curative effect of patients with sudden deafness of high-frequency descending type.Results: There were statistically significant differences in blood lipid indices(TC,TG,LPa,HDL-C,and LDL-C),blood coagulation index(APTT)and blood routine index(NEUT)between experimental group and control group(P<0. 05), while there were no statistically significant differences in nonestesterified fatty acid(NEFA), blood coagulation indices(FIB and PT), and blood routine indices(PLT and WBC)between the two groups(P>0. 05). In addition, TC, APTT, age, accompanying with vertigo, degree of hearing loss, and treatment time showed obvious correlation to the curative effect(P<0. 05).Conclusion: Patients with high-frequency descending sudden deafness have higher blood lipid indices(TC, TG, LPa, and LDL-C), blood coagulation index(APTT), blood routine index(NEUT)and lower HDL-C. High TC and APTT levels, aged over 50, vertigo, severe hearing loss, and the later treatment are related to the poor prognosis.