高压氧联合丁苯酞对老年脑梗死后血管性痴呆患者神经功能及认知功能的影响

Effects of Hyperbaric Oxygen Combined with Butylphthalein on Neurological Function and Cognitive Function in Elderly Patients with Vascular Dementia after Cerebral Infarction

目的探讨高压氧联合丁苯酞对老年脑梗死后血管性痴呆患者神经功能及认知功能的影响。方法选择该院2020年3月—2023年3月收治的82例老年脑梗死后血管性痴呆患者为研究对象,按随机数字表法将其分为对照组与观察组,各41例。对照组采用丁苯酞治疗,观察组采用高压氧联合丁苯酞治疗。比较两组患者的神经功能、认知功能、记忆能力、不良反应发生情况。结果治疗后,观察组美国国立卫生研究院卒中量表评分低于对照组,简易精神状态检查量表评分高于对照组,组间差异有统计学意义(P<0.05)。观察组临床记忆量表的各个维度评分均高于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论高压氧联合丁苯酞可改善老年脑梗死后血管性痴呆患者神经功能及认知功能,增强其记忆力,安全性较好。

Objective To investigate the effects of hyperbaric oxygen combined with butylphthalide on neurological function and cognitive function in elderly patients with vascular dementia after cerebral infarction.Methods A total of 82 elderly patients with vascular dementia after cerebral infarction admitted to the hospital from March 2020 to March 2023 were selected as the study objects,and they were divided into a control group and an observation group according to random number table method,with 41 cases in each group.The control group was treated with butylphthalein,and the observation group was treated with hyperbaric oxygen combined with butylphthalein.Neurological function,cognitive function,memory ability and adverse reactions were compared between the two groups.Results After treatment,the score of the National Institutes of Health Stroke Scale in the observation group was lower than that in the control group,and the score of the Mini Mental state Examination Scale was higher than that in the control group,with statistical significance(P<0.05).The scores of all dimensions of Clinical Memory Scale were higher than those of control group,and the differences between groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Hyperbaric oxygen combined with butylphthalein can improve the neurological function and cognitive function of elderly patients with vascular dementia after cerebral infarction,enhance their memory,and has good safety.