磁悬浮式体外凝血功能动态检测传感器

Magnetic levitation in-vitro coagulation function dynamic detection sensor

针对传统体外凝血动态检测传感器弹性支撑易疲劳而引起传感器精度降低的关键问题,设计一种基于磁悬浮方式的体外凝血检测新型传感器。根据体外凝血检测传感器工作原理及结构特点,建立传感器内部磁悬浮空间状态数学模型,通过不同相位角的排布对传感器内部结构进行电磁结构仿真,采用有限元数值分析法对相位角与磁感应强度的关系进行分析,优化分析结果并搭建实验测试装置。利用本装置对传感器进行参数标定,验证传感器磁悬浮排布结构设计结果,并通过与标准粘度溶液配套测试与进口仪器进行数据比对。结果表明,本文设计的磁悬浮式体外凝血功能动态检测传感器相位角在20°时产生的内部磁感应强度为1.46e·10;Wb/m,与仿真数据基本吻合,此时传感器的振幅为2.03μm,振动频率为150 Hz,测试数据重复性与相关性分别为0.003、0.994,经过计算传感器精度为0.002 MPa·s。本文设计的凝血功能动态检测传感器精度可以满足体外凝血检测的要求,为改善产品性能方面提供核心技术保障,在提升临床凝血快速检测技术中发挥重要的作用。

Aiming at the key problem that the elastic support of the traditional in vitro coagulation dynamic sensor is easy to fatigue,which leads to the decrease of sensor accuracy,a new in-vitro coagulation dynamic sensor based on magnetic levitation was designed.Based on blood coagulation in vitro detection sensor working principle and structural characteristics,the mathematical model of the magnetic space status inside the sensor through the arrangement of different phase angle sensor internal structure for electromagnetic structure simulation,finite element numerical analysis on the relationship between the phase angle and the magnetic induction intensity were analyzed,and the optimization analysis results and set up the experimental test equipment.The device was used to calibrate the parameters of the sensor,verify the design results of the magnetic levitation arrangement structure of the sensor,and compare the data with the imported instrument through matching test with the standard viscosity solution.The results show that when the phase angle of the magnetic levitation sensor designed in this paper is 20°,the internal magnetic induction intensity is 1.46 e·10;Wb/m,which is basically consistent with the simulation data.At this time,the amplitude of the sensor is 2.03μm,and the vibration frequency is 150 Hz.The repeatability and correlation of the test data were 0.003 and 0.994,respectively.After calculation,the sensor accuracy was 0.002 MPa·s.The precision of the dynamic detection sensor of coagulation function designed in this paper can meet the requirements of in vitro coagulation detection,provide core technical guarantee for improving product performance,and play an important role in improving clinical coagulation rapid detection technology.