噻托溴铵吸入联合综合性呼吸康复治疗对慢性阻塞性肺疾病稳定期患者肺功能的影响

Effects of Tiotropium Bromide Inhalation Combined with Comprehensive Respiratory Rehabilitation Treatment on Pulmonary Function in Patients with Chronic Obstructive Pulmonary Disease at Stable Stage

目的探究慢性阻塞性肺疾病(COPD)稳定期患者采用噻托溴铵吸入联合综合性呼吸康复治疗对其肺功能的影响.方法选取我院2020年3月—2022年3月收治的86例COPD稳定期患者为研究对象,按随机数字表法分为对照组(n=43)和观察组(n=43).对照组采用噻托溴铵吸入治疗,观察组在对照组基础上联合采用综合性呼吸康复治疗,均持续治疗1个月.比较两组肺功能、运动耐力、生活能力以及生活质量.结果治疗前,两组肺功能、运动耐力、生活能力以及生活质量比较,组间差异无统计学意义(P>0.05);治疗后,观察组第1秒用力呼气容积(FEV_(1))(1.73±0.25)L大于对照组,FEV_(1)占预计值百分比(66.37±6.54)%、FEV_(1)/用力肺活量(68.59±5.74)%均高于对照组,6 min步行试验距离(395.84±23.67)m长于对照组,Barthel指数评定量表评分(82.29±3.42)分高于对照组,COPD评估测试量表评分(13.54±1.27)分低于对照组,组间差异有统计学意义(P<0.05).结论噻托溴铵吸入联合综合性呼吸康复治疗能够有效增强COPD稳定期患者的运动耐力,改善其肺功能,提高其生活能力及生活质量.

Objective To explore the effect of tiotropium bromide inhalation combined with comprehensive respiratory rehabilitation treatment on pulmonary function in patients with chronic obstructive pulmonary disease(COPD)at stable stage.Methods 86 patients with COPD at stable stage who were treated in the hospital from March 2020 to March 2022 were selected as the research objects,and were divided into a control group(n=43)and an observation group(n=43)according to random number table method.The control group was treated with tiotropium bromide inhalation,and the observation group was treated with comprehensive respiratory rehabilitation treatment on the basis of the control group,both groups continued treatment for 1 month.Pulmonary function,exercise endurance,life ability and quality of life were compared between the two groups.Results Before treatment,there was no significant difference in pulmonary function,exercise endurance,life ability and quality of life between the two groups(P>0.05);after treatment,the forced expiratory volume in one second(FEV_(1))of the observation group was(1.73±0.25)L,which was greater than that of the control group,the FEV_(1)as a percentage of expected value was(66.37±6.54)%,and the FEV_(1)/forced vital capacity was(68.59±5.74)%,which were higher than those in the control group,the distance of the 6 min walk test was(395.84±23.67)m,which was longer than that of the control group,the Barthel index score was(82.29±3.42)points,which was higher than that of the control group,the COPD assessment test score was(13.54±1.27)points,which was lower than that of the control group,and the differences between the groups were statistically significant(P<0.05).Conclusion Tiotropium bromide inhalation combined with comprehensive respiratory rehabilitation treatment can effectively enhance exercise endurance,improve pulmonary function,improve living ability and quality of life of COPD patients in stable stage.