布地奈德联合特布他林对先天性心脏病合并喘息性肺炎患儿炎性因子水平的影响

Effect of Budesonide Combined with Terbutaline on the Levels of Inflammatory Factors in Children with Congenital Heart Disease Complicated with Asthmatic Pneumonia

目的探讨先天性心脏病合并喘息性肺炎患儿采用特布他林联合布地奈德治疗对其炎性因子水平的影响.方法选择2020年1月—2021年6月该院收治的80例先天性心脏病合并喘息性肺炎患儿为研究对象,按照随机数字表法分为两组,各40例.对照组采用布地奈德治疗,观察组采用布地奈德联合特布他林治疗,均连续治疗21 d.比较两组症状改善情况、治疗前后炎性因子水平及QT离散度、不良反应.结果观察组肺鸣音、气促、咳嗽消失时间以及退热时间均较对照组更短,组间差异有统计学意义(P<0.05).治疗后,两组血清C反应蛋白(CRP)水平均较治疗前更低,且观察组CRP水平低于对照组,组间差异有统计学意义(P<0.05).两组治疗前、后的QT离散度比较,差异无统计学意义(P>0.05);两组治疗后的QT离散度与治疗前比较,差异无统计学意义(P>0.05).观察组治疗期间不良反应发生率10.00%与对照组的5.00%比较,差异无统计学意义(P>0.05).结论先天性心脏病合并喘息性肺炎患儿采用特布他林联合布地奈德治疗,可有效调节炎症因子水平,改善临床症状,且未增加不良反应,安全性好.

Objective To investigate the effect of terbutaline combined with budesonide on the levels of inflammatory factors in children with congenital heart disease complicated with asthmatic pneumonia.Methods 80 children with congenital heart disease combined with asthmatic pneumonia who were admitted to the hospital from January 2020 to June 2021 were selected as the research objects,and divided into two groups according to the random number table method,with 40 cases in each group.The control group was treated with budesonide,and the observation group was treated with budesonide combined with terbutaline.Both groups were treated for 21 days.The symptom improvement,inflammatory factor levels and QT dispersion before and after treatment and adverse reactions were compared between the two groups.Results The time to disappearance of lung sound,shortness of breath,cough and fever in the observation group were shorter than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the levels of serum Creactive protein(CRP)in the two groups were lower than those before treatment,and the CRP level in the observation group was lower than that in the control group,and the differences between the two groups were statistically significant(P<0.05).There was no significant difference in the QT dispersion between the two groups before and after treatment(P>0.05);there was no significant difference in the QT dispersion between the two groups after treatment compared with that before treatment(P>0.05).The incidence of adverse reactions in the observation group during the treatment period was 10.00%,compared with 5.00%in the control group,the difference was not statistically significant(P>0.05).Conclusion The combination of terbutaline and budesonide in the treatment of children with congenital heart disease and asthmatic pneumonia can effectively regulate the level of inflammatory factors and improve clinical symptoms without increasing adverse reactions,with good safety.