柴胡加龙骨牡蛎汤加减治疗乳腺癌术后放化疗致睡眠障碍的康复效果

Rehabilitation Effect of Chaihu plus Longgu Muli Decoction on Sleep Disturbance Caused by Radiotherapy and Chemotherapy after Breast Cancer Surgery

目的探讨柴胡加龙骨牡蛎汤加减治疗乳腺癌术后放化疗致睡眠障碍的临床康复效果。方法选取2019年2月—2020年5月期间在该院放化疗后出现睡眠障碍的69例乳腺癌患者,随机分为艾司唑仑组(34例)和汤剂组(35例)。艾司唑仑组口服艾司唑仑片,汤剂组在艾司唑仑组基础上增加柴胡加龙骨牡蛎汤加减治疗。观察两组治疗前后睡眠质量、抑郁焦虑情绪改善及生活质量情况。结果治疗后汤剂组焦虑、抑郁自评量表得分低于艾司唑仑组,生存质量得分高于艾司唑仑组,组间差异均有统计学意义(P<0.05)。汤剂组治疗后匹兹堡睡眠质量评分(6.02±2.03)分和每夜觉醒次数(1.26±0.48)次显著低于艾司唑仑组[(10.24±5.26)分、(2.06±0.78)次],每晚睡眠时间(6.85±1.98)h显著高于艾司唑仑组(5.79±1.56)h,组间差异有统计学意义(P<0.05)。结论柴胡加龙骨牡蛎汤对乳腺癌术后放化疗致睡眠障碍的治疗效果良好,可有效提升患者睡眠质量,延长睡眠时间,并可改善患者抑郁与焦虑情绪,提升患者生活质量。

Objective To investigate the clinical rehabilitation effect of Chaihu plus Longgu Muli Decoction in the treatment of sleep disorders after breast cancer surgery caused by radiotherapy and chemotherapy.Methods From February 2019 to May 2020,69 breast cancer patients who suffered sleep disorders after radiotherapy and chemotherapy were selected and randomly divided into estazolam group(34 cases)and decoction group(35 cases).The eszolam group was given oral eszolam tablets,and the decoction group added Chaihu plus Longgu Muli Decoction on the basis of the eszolam group.The improvement of sleep quality,depression and anxiety mood and quality of life in the two groups before and after treatment were observed.Results After treatment,the anxiety and depression self-rating scale scores of the decoction group were lower than those of the estazolam group,and the quality of life scores were higher than that of the estazolam group,the differences between the groups were statistically significant(P<0.05).After treatment,the Pittsburgh sleep quality score(6.02±2.03)points and the number of night awakenings(1.26±0.48)times in the decoction group were significantly lower than those in the estazolam group[(10.24±5.26)points,(2.06±0.78)times],the sleep time per night(6.85±1.98)h was significantly higher than the estazolam group’s(5.79±1.56)h,and the differences between the groups were statistically significant(P<0.05).Conclusion Chaihu plus Longgu Muli Decoction has a good effect on the treatment of sleep disorders caused by chemotherapy and radiotherapy after breast cancer surgery.It can effectively improve the quality of sleep and prolong sleep time,improve depression and anxiety,and improve the quality of life of patients.