摘要
Objective:To study the effect of ulinastatin combined with CRRT therapy on the endothelial oxidative damage and inflammatory injury in patients with acute respiratory distress syndrome (ARDS).Methods: A total of 60 patients with ARDS who were treated in our hospital between April 2011 and April 2016 were collected and divided into the control group (n=29) who received pure CRRT therapy and the combined treatment group (n=31) who received ulinastatin combined with CRRT therapy after the therapy and related laboratory examination were reviewed. Before treatment and after 5d of treatment, enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of endothelial function indexes and inflammation indexes in serum and exhaled breath condensate;RIA method was used to detect the levels of oxidative stress indexes in serum and exhaled breath condensate.Results: Before treatment, the differences in the endothelial function, oxidative stress and inflammation indexes in serum and exhaled breath condensate were not statistically significant between two groups of patients. After treatment, endothelial function index NO levels in serum and exhaled breath condensate of observation group were higher than those of control group while ET-1 levels were lower than those of control group;oxidative stress indexes CAT and SOD levels in serum and exhaled breath condensate of observation group were higher than those of control group while MAO levels were lower than those of control group;inflammation indexes PCT, IL-1β and HMGB1 levels in serum and exhaled breath condensate of observation group were lower than those of control group.Conclusion: Ulinastatin combined with CRRT therapy can improve the endothelial function and reduce the oxidative stress and inflammatory injury in patients with ARDS.
