Evaluation of systemic impact of tricuspid regurgitation:an appeal for the notion of tricuspid regurgitation syndrome

Tricuspid regurgitation(TR)is an often encountered but undertreated valvular heart lesion.Unlike left-sided valvular diseases,it is estimated that only 5%of patients with significant TR were treated surgically,among which 86%were treated in combination with other major procedures.[1]This unmet need partially resulted from the lack of prospective evidence on reduced mortality of severe TR benefiting from surgery,alongside a historical viewpoint that functional TR(being the etiology for the vast majority of TR)would be improved once problems in the left heart are corrected.However,untreated severe TR shows various symptoms and a poor prognosis,including increased early and late mortality and impaired quality of life.[2]With the rapid development of catheter-based valve therapies,less invasive treatment options have been offered to the once forgotten tricuspid valve,further expanding the complexity of decision-making for TR intervention.