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急性颅脑损伤患者血清S100B蛋白动态检测的意义 被引量:7

Investigation of serum S100B protein in acute brain injury patients
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摘要 目的:探讨血清S100B蛋白作为一种生物学指标在颅脑损伤诊断及预后判断中的应用价值。方法:颅脑损伤40例,伤后4 h、24 h、72 h、7 d抽取血液标本,以ELISA法检测血清S100B蛋白含量,以GCS≤8分者为重伤组,共24例,以GCS≥9分者为非重伤组,共16例,比较两组在各个时间点的血清S100B蛋白含量有无差异性,另将其结果与患者伤后6个月格拉斯哥预后评分(GOS)进行比较。结果:两组伤后4 h、24 h血清S100B蛋白含量均增高,且于24 h达到高峰,伤后一周趋于正常。重伤组伤后24 h、72 h的S100B蛋白含量与非重伤组相比差异有统计学意义(P<0.05)。40例患者中预后恶劣组9例,预后良好组31例,预后恶劣组平均血清S100B蛋白含量明显高于预后良好组(P<0.01);预后恶劣组中伤后7天血清S100B在正常水平以上的有4例,预后良好组中血清S100B在正常水平以上仅有2例,两组相比差异有统计学意义(P<0.01)。结论:血清S100B蛋白在重型颅脑损伤的诊断及预后判断中具有可靠的应用价值。 Objective: To investigate the value of S100B protein as a biological marker in predicting the probable outcome of cerebral injury.Methods: 40 cases with head injury were included in this study,venous blood samples for S100B protein were obtained after 4 h、24 h、72 h、7 d.The serum concentrations of S100B protein were measured.Serum levels of S100B protein were compared with the outcome after 6 months,using Glasgow outcome scale score(GOS).Results: The differences of S100B protein between severe brain injury p...
作者 葛忆秦 程英
出处 《南通大学学报(医学版)》 2008年第3期185-186,188,共3页 Journal of Nantong University(Medical sciences)
关键词 颅脑损伤 S100B蛋白 预后 Brain injury S100B protein Prognosis
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  • 1王尤洪,吴添平,戴建明,谭美娟,吴克松,吴振宏,周淑玉.急性颅脑损伤后56例垂体前叶激素变化分析[J].南通大学学报(医学版),2008,28(3):203-204. 被引量:4
  • 2梅杰,张光辉.颅脑损伤对机体免疫功能的影响[J].中国临床神经外科杂志,2005,10(3):237-239. 被引量:10
  • 3甘国胜,祝松,陈利民,陈敏,林俊明.急性颅脑外伤手术患者血清S100β的测定及意义[J].解放军医学杂志,2007,32(2):173-173. 被引量:2
  • 4黄友敏,张厚毅,周永勤,续继军.脂联素及血高敏C-反应蛋白与急性脑损伤的关系[J].中华急诊医学杂志,2007,16(6):579-582. 被引量:24
  • 5Foerch C,Singer OC,Neumann-Haefelin T,et al.Evaluation of serum S100B as a surrogate marker for long-term outcome and infarct volume in acute middle cerebral artery infarction[J].Arch Neurol,2005,62(7):1130-1134.
  • 6Lyden P,Brott T,Tilley B,et al.Improved reliability of the NIH stroke scale using video training[J].Stroke,1994,25(11):2220-2226.
  • 7Steiner J,Bernstein HG,Biehu H,et al.Evidence for a wide extraastro-cytic distribution of S100B in human brain[J].BMC Neurosci,2007;8:2
  • 8Adami C,Sorci G,Blasi E,et al.S100B expression in and effects on microglia[J].Glia,2001;33:131
  • 9Ghanem G,Loir B,Morandini R,et al.On the release and half-life of S100B protein in the peripheral blood of melanoma patients[J].Int J Cancer,2001;94:586
  • 10Carlos Alberto Goncalves,Marina Concli Leite,Patricia Nardin.Biological and methodological features of the measurement of S100B,a putative marker of brain injury[J].Clinical Biochenistry,2008;41:755

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