纳络酮治疗急性酒精中毒的临床疗效观察

Observing the Effect of Naloxone on Acute Alcoholism

目的:评价纳络酮治疗急性酒精中毒的临床疗效。方法:将78例非糖尿病酒精中毒的患者随机分为两组,治疗组40例,对照组38例,两组在性别、年龄及病因等方面无差异性(P>0.05)。两组均常规给予洗胃、补液,保护胃粘膜,制酸治疗。治疗组同时给予纳络酮0.4mg静推,严重患者间隔30m in可重复使用1次,随后给予10%Gs250m l+纳络酮0.8mg静滴。结果:纳络酮治疗组患者症状改善,清醒时间明显提前于对照组。结论:纳络酮是治疗急性酒精中毒的安全有效的药物。

Objective: To evaluate the clinical effect of naloxone on acute alcoholism.Method: 78 cases of non-diabetes alcoholism were randomly divided into two groups: the remedial group(40 cases) and the comparison group(38 cases).There's no difference(P>0.05) in sex,age and cause of disease between two gronp.Both groups were given gastric lavage,fluid infusion,protection of mucous membrane of stomach and inhibition of gastric acid.The remedial group was given vein infusion of 0.4mg Naloxone.The severe ones were given vein infusion again after 30 minutes.Then,vein instillation of 10%GS250ml + Naloxone0.8mg was given.Result: Symptoms of the remedial group were obviously improved.Consciousness was regained much earlier than that of the comparison group.Conclusion: Naloxone can be used effectively and safely in treating acute alcoholism.