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促炎细胞因子对肠上皮细胞紧密连接调控的分子机制 被引量：6

Molecule mechanisms of the pro-inflammatory cytokine's effect on intestinal epithelium tight junctions
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摘要 促炎细胞因子是由细胞分泌的、具有促进和调节炎性反应作用的小分子多肽,主要有IL-1、IL-6、肿瘤坏死因子-α(TNF-α)、γ-干扰素(IFN-γ)等。炎症性肠病病人血清中促炎细胞因子水平显著增高,并且能引起肠上皮细胞紧密连接的改变。现就促炎细胞因子对肠上皮细胞紧密连接调控的分子机制作一综述,旨在为开展基础研究和临床提供参考。 The pro-inflammation cytokine is secreted by cells,and the function is to promote and regulate inflammatory reactions.They include IL-1,IL-6,TNF-α and IFN-γ.Researchs have revealed that the levels of serum pro-inflammation cytokinemight increase notably in inflammatory bowel disease patients and they could cause the change of intestinal epithelium tight junctions.
作者 顾立立 李宁
机构地区 第二军医大学南京临床医学院(南京军区南京总医院)解放军普通外科研究所
出处 《肠外与肠内营养》 CAS 2008年第2期114-118,共5页 Parenteral & Enteral Nutrition
基金 南京军区医药科研项目重大专项资助(07Z026)
关键词 促炎细胞因子 肠上皮 紧密连接 分子机制 Pro-inflammation cytokine Intestinal epithelium Tight junctions Molecular mechanism
分类号 R574 [医药卫生—消化系统]
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参考文献43

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二级参考文献32

  • 1秦环龙,高志光.肠上皮细胞紧密连接在肠屏障中的作用研究进展[J].世界华人消化杂志,2005,13(4):443-447. 被引量：37
  • 2李晓芳.严重烧伤后胃肠道功能障碍的机制和防治[J].世界华人消化杂志,2006,14(9):888-893. 被引量：17
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肠外与肠内营养
2008年 第2期

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