胃溃疡合并慢性乙型肝炎患者胃黏膜产生免疫球蛋白的细胞活性的影响研究

Study on effect of functional activity of immunnoglobulin-producing cells in gastric mucosa in patients with gastric ulcer accompanied with chronic hepatitis B

目的对胃溃疡合并慢性乙型肝炎(下称乙肝)患者的胃黏膜产生免疫球蛋白的细胞进行研究。方法研究组为52例胃溃疡合并慢性乙肝患者,对照组为24例单纯胃溃疡患者。以尿素酶试验及组织Giemsa染色法检测幽门螺杆菌(Hp);以免疫组织化学SABC法检测胃黏膜免疫球蛋白产生细胞。结果单纯胃溃疡患者无论Hp检测是否为阳性,胃黏膜免疫球蛋白产生细胞均以IgA产生细胞为主。而胃溃疡合并慢性乙肝患者,产生IgA细胞明显减少,合成IgM及IgG细胞明显增多,尤以Hp阳性患者为著。结论胃溃疡合并慢性乙肝患者胃黏膜免疫状态发生了改变,对Hp的清除和溃疡的愈合可能产生不利的影响。

Objective To investigate the immunoglobulin-producing cells in gastric mucosa in the patients with gastric ulcer accompanied with chronic hepatitis B(CHB).Methods The study group included 52 patients with gastric ulcer accompanied with CHB,and the control group included 24 patients just with gastric ulcer.Helicobacter pylori (Hp) in gastric mucosa from all patiens were detected by urease test and Giemsa staining assay.Immunoglobulin-producing cells in gastricmucosa were studied by immunohistochemistry SABC technique.Results IgA-producing cells in gastric mucosa were absolutely dominant in the patients with gastric ulcer whether the detection of Hp was positive or negative. In the patients with gastric ulcer accompanied with CHB,however,IgA-producing cells in gastric mucosa were significantly decreased,IgM and IgG-producing cells markedly increased,and this state was espercially marked in Hp positive cases.Conclusion The immune status of gastric mucosa is altered in patients with gastric ulcer accompanied with CHB,and the change may interrupt the clearance of Hp and the healing of gastric ulcer.