菊麦茶饮对衰老大鼠学习记忆能力和脑老化的影响

Effect of Jumai Tea Beverage on Learning Memory and Anti-aging in Aging Rats

目的观察菊麦茶饮对衰老模型大鼠学习记忆能力及脑老化的影响。方法75只Wist-ar大鼠连续8周皮下注射7.5%D-半乳糖建立衰老模型,同时灌服菊麦茶饮,8周后采用Morris水迷宫法检测大鼠学习记忆能力,处死取脑并测定脑组织中MDA含量、SOD及MAO-B活性。结果菊麦茶饮可以明显改善衰老大鼠的学习记忆能力,提高衰老大鼠脑内SOD活性,降低衰老大鼠脑内MDA含量和MAO-B活性。结论菊麦茶饮能够提高衰老大鼠学习记忆能力以及具有延缓脑老化的作用(抗衰老作用)。

Objective To observe the effects of Jumai Tea Beverage on learning and memory and Anti-aging in aging rat models.Methods The aging rat models were established by intraperitoneally injection of 7.5%D-galactose at dose of 75mg/kg once a day for 8 weeks,at the same time,some of the rat models were given Jumai Tea Beverage via gastrogavage,Morris water maze was used to determine learning and memory in aging rats at the end of the 8th week.The brain tissue were collected after 9 weeks of experiment,the contents of MDA and MAO-B and the activity of SOD were measured.Results Jumai Tea Beverage could significantly improve learning and memory,elevate the activity of SOD and lower the content of MDA and MAO-B.Conclusions Jumai Tea Beverage can improve learning memory and delay brain aging in aging rats.