孕中期母血产前筛查回顾性分析

Retrospective study on Serum prenatal screen in pregnancy review analysis

目的对柳州地区3299例孕中期妇女产前筛查结果进行回顾性分析,建立适合本实验室的血清AFP中位数值,探讨进行筛查的最佳孕周。方法用酶联免疫法(ELISA)对孕妇血清AFP和Free-βhCG进行检测,并结合孕妇年龄、孕周、体重、有无糖尿病等,采用配套软件估算风险概率。应用EXCEL计算本地区孕妇AFP中位数,比较标化前后检测结果,并对各孕周筛查风险概率进行比较。结果在3299例孕中期妇女中,DS和神经管缺陷筛查阳性率分别为8.73%和3.30%,检出先天缺陷10例。柳州地区孕中期妇女AFP中位数比内嵌软件中位数平均高9.43%,校正后NTD筛查敏感度提高10.08%;孕14、15、19周筛查阳性率分别为9.26%、8.09%、7.74%,高于其它各孕周筛查阳性率。结论血清AFP、HCG联合检测,可作为柳州地区孕中期产前筛查优选项目,建立适合本地区的中位数值可提高筛查的准确度,建议以孕16、17、18周为最佳筛查孕周。

Objectives:Reviewed 3299 cases of prenatal screen results in the middle of pregnancy in Liuzhou region,to establish the suitable serum AFP median in this laboratory,and to establish the best time of prenatal screen.Methods:Measuring the serum AFP,HCG in pregnant women with ELISA,and combined with other factors:age,weeks of pregnancy,weight,diabetes history,etc.Estimate the risk rate of dieases with inside software.Computed the AFP median in pregnant women in this region with EXCEL,compared the detecting eff...