摘要
目的:探讨蚤休总皂甙对大鼠动脉内皮保护的作用。方法:用蚤休总皂甙治疗高脂血症大鼠,并测定血脂。主动脉内皮细胞铺片内皮素(ET)-1和内皮源型一氧化氮合酶(eNOS)阳性细胞率、血浆 ET-1和 eNOS 浓度、主动脉中膜平滑肌细胞(SMC)ET-1阳性率和厚度。结果:蚤休总皂甙不降血脂,但使动脉内皮细胞合成和释放 ET-1显著减少(P<0.05);血浆 eNOS 浓度用药后主动脉中膜平滑肌细胞 ET-1阳性率以及中膜 SMC 层厚度与模型组比较差异无显著性。结论:蚤休总皂甙通过使动脉内皮细胞合成及释放 ET-1减少,而起到保护动脉内皮细胞的作用。
Objective:To investigate the protective effect of Paris saponin(PS)on arterial endothelium.Methods:Hyperlipidemia rats were treated with PS,the blood lipids,endothelin(ET)in arterial endothelium,endothelial originated nitric oxide synthase(eNOS)positive rate,plasma endothelin-1(ET-1)and endothelial nitric oxide synthase(eNOS)concentration,ET-1 positive rate and thickness of aortic mid-membranous smooth muscle cell(SMC)were determined.Results:PS didn t lower the blood lipids,but significantly reduce the syn-...
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2002年第S1期7-9,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
山东省中医药管理局资助项目(No.1998-CA-2CAA2)
