摘要
目的研究重组人促红细胞生成素(rHuEPO)对大鼠皮肤深Ⅱ°烫伤愈合的影响。方法健康SD大鼠随机分成低剂量组(50U/mL rHuEPO)、中剂量组(100U/mL rHuEPO)、高剂量组(200U/mL rHuEPO)和生理盐水(NS)对照组,建立深Ⅱ°烫伤动物模型,并于伤后3、5、7、14、21d取创面皮肤标本,HE染色和免疫组织化学方法染色分别检测创面愈合情况及微血管密度。结果与对照组相比,rHuEPO治疗组创面愈合时间缩短,同一时相内大鼠烫伤愈合率高于对照组,微血管密度明显增加。结论rHuEPO能促进深Ⅱ°烫伤创面微血管形成,加速创面愈合。
Objective To observe the effect of recombinant human erythropoietin on deep second degree scald wound healing of rats skin. Methods A model of deep second degree scald wound in rats was used, All healthy SD rats were randomly divided into four groups: low-doze group (50 U / ml rHuEPO), mid-doze group (100 U / ml rHuEPO), high-doze group(200 U / ml rHuEPO)and NS control group, the process of deep second degree scald wound healing were observed on the level of micropathology with HE staining, and microvessal ...
出处
《解剖学研究》
CAS
2008年第6期435-437,共3页
Anatomy Research
基金
武汉科技大学大学生科技创新基金(2007089)
