两种不同剂量米非司酮配伍米索前列醇终止中期妊娠引产的临床研究

Clinical Study on Two Different Dosages of Mifepristone Combined with Misoprostol in Midtrimester Termination

目的:探讨对14周～27周妊娠使用两种不同剂量米非司酮配伍米索前列醇的引产效果。方法:将180例妊娠14孕周～27孕周自愿要求终止妊娠者分成研究组(A组)米非司酮总量300mg联合米索前列醇,对照组(B组)米非司酮总量150mg联合米索前列醇,对照组(C组)利凡诺组。观察三组的总产程,产后2h出血量,胎盘、胎膜残留情况,引产成功例数等情况。结果:对于14周～27周中期妊娠引产者,A组较B组、C组总产程短,产后2h出血量少,胎盘、胎膜残留率低。结论:米非司酮配伍米索前列醇可以用于临床14周～27周中期妊娠引产,增加米非司酮的剂量能提高其终止14周～27周妊娠的疗效,临床上值得推广。

Objective To investigate the effectiveness of regimens that include mifepristone of two different doses followed misoprostol for the termination of 14-27 weeks gestation .Methods 180 cases of their own accord in 14-27weeks pregnancy were divided into three groups randomly.Study group A took 300 mg mifepristone followed misoprostol.Control group B took 150 mg mifepristone followed misoprostol.Control group C only used Rivanol.Evaluating following indices in the three groups,including total labor time,postpar...