联用左氧氟沙星治疗涂阳重度肺结核病的疗效分析

Analysis of the treatment using levofloxacin combined with other anti-tuberculosis drugs to serious smear-positive pulmonary tuberculosis

目的分析新型抗结核药物左氧氟沙星联合其他抗结核药物治疗重度肺结核患者的治疗效果和安全性。方法对100例重症肺结核患者采用1∶1随机、平行对照的方法,分为左氧氟沙星治疗组(治疗组)和常规治疗组(对照组),完成6个月疗程后,随访2年,进行统计分析。结果治疗组和对照组的痰菌阴转情况、药物不良反应情况差异无统计学意义;胸部X线显示病灶吸收率治疗组和对照组的差异有统计学意义,治疗2月末为72%和46%,(χ2=9.24,P<0.01);治疗6月末为78%和52%,(χ2=7.428,P<0.01)。结论初治涂阳的重症肺结核患者可考虑联用左氧氟沙星抗结核治疗,提高治疗效果。

Objective To analysis the curative effect and safety of levofloxacin combined with other anti-tuberculosis drugs on the treatment of serious smear-positive pulmonary tuberculosis(P-TB)cases.Methods During 6 months treatment,100 patients with serious smear-positive P-TB were divided into group including levofloxacin and control group with proportion 1∶1 random,parallel comparing method.At the end of full treatment courses,the patients were followed-up for 2 years.Results They had not significant deference between the two groups on the sputum negative conversion rates and the adverse drug reactions incident rates.The remarkable effective rates in chest X-ray of the two groups were 72% and 46% respectively,(χ2=9.24,P<0.01),at the second month end of treatment,78% and 52%,(χ2=7.428,P<0.01),at the sixth month end of treatment.Conclusion Levofloxacin combined with other anti-TB drugs may be used in serious initial sputum positive P-TB patients.It can improve the curative effect on anti-TB.