治疗婴幼儿轮状病毒腹泻的药物临床药理学分析

目的探讨西咪替丁联合思密达对婴幼儿轮状病毒(RV)腹泻的治疗作用。方法自2002年1月～2006年1月我们在治疗大便RV抗原检测阳性的腹泻婴幼儿298例中,随机分为2组,治疗组153例,用西咪替丁10～20mg/(kg·d)静滴,加思密达口服,对照组145例,用病毒唑10～15mg/(k6·d)静滴,加止泻药进行对比性研究。结果治疗组、对照组总有效率分别为95.4%、75.2%(χ2=26.87,P<0.001),差异有非常显著性,其中发病3天以内者显效达81.2%,总有效率为97.9%,迁延性者显效66.7%,总有效率为90.5%;慢性者显效50%,总有效率为75%。结论西咪替丁联合思密达治疗婴幼儿轮状病毒腹泻疗效显著,且早期用药可提高疗效,值得临床推广。

Objective To study the effect of cimetidine plus smectite combination treatment for rotavirus diarrhea in infants. Methods During 2002 Jan to Jan 2006, 298 patients with rotavirus diarrhea were diagnosed by rotavirus antigen titer in stools, were divided into treatment group (n= 153) and control group (n=145 ) .Cimetidine and smectite were given in treatment group, virazole and other antidiarrheic were given in control group. Results In the treatment and control group, overall effectiveness rates were 95.4% and 75.2%, respectively. There were significant differences between the two groups (χ2=26.87, P <0.001). In acute (course<3d) , postonent and chronic the diarrhea, the palpable effects and overall effectiveness were 81.2% and 97.9%, 66.7%and 90.5%, 50% and 75%, respectively. Conclusions Cimetidine plus smectite has a good therapeutic effect for rotavirus diarrhea in infants, that is better effect in early stage of illness, it is worthy of spreading.