超敏C-反应蛋白与急性动脉粥样硬化性脑梗死关系的研究

The Relationship between Highly Sensitive C Reactive Protein and Acute Atberosclerotic Cerebral Infarction

目的研究血清超敏C-反应蛋白(hs-CRP)与急性动脉粥样硬化性脑梗死之间的关系。方法回顾性分析297例动脉粥样硬化性脑梗死(ATCI)患者血清hs-CRP水平及其与年龄、性别、危险因素、梗死灶体积、病情轻重程度的关系。另选40例健康对照者,测定其血清hs-CRP水平,并与ATCI组患者比较。结果动脉粥样硬化性脑梗死组患者血清hs-CRP水平明显高于对照组,两组间差别有显著性意义(P＜0．01);血清hs-CRP水平与梗死灶体积、病情轻重程度呈正相关(P＜0．05),尤以梗死灶体积更为明显,且三者之间呈明显正相关:血清hs- CRP水平与年龄、性别及有无高血压病等常见危险因素无关(P＞0．05)。结论血清hs-CRP水平可作为评价动脉粥样硬化性脑梗死病变程度的一个重要指标。

Objective To study the relationship between serum C reactive protein (CRP) and acute atherosclerotic cerebral infarction (ATCI).Methods The 297 patients with acute atherosclerotic cerebral infarction were tested the concentra- tion of highly sensitive C reactive protein (hs-CRP) in blood serum with immune-dispersion-turbidimetric-method,then their clinical data,NIHSS,and infarction volume were retrospectively collected.The controll group included 40 healthy people who were tested the hs-CRP.Results The concentration of hs-CRP in ATCI group was much higher than that of the controll group (P＜0.01).The hs-CRP concentration was positively correlative with the infarction volume and severity of the illness, especially with the intarction volume.The hs-CRP concentration had no correlations with age,gender and other atherosclerotic risk factor.Conclusion The concentration of hs-CRP in blood serum may be an important assessment of the disease severity.