失代偿性肝硬化患者血清VEGF、TGF-β_1、TNF-α检测及临床意义

Detection and significance of serum VEGF,TGF-β_1,TNF-α in patients with decompensated liver cirrhosis

目的:检测失代偿性肝硬化(DLC)患者血清血管内皮生长因子(VEGF)、转化生长因子β1(TGF-β1)、肿瘤坏死因子-α(TNF-α)水平,探讨血清VEGF、TGF-β1、TNF-α对DLC预后判断的意义。方法:选择DLC患者86例,同步测定血清VEGF、TGF-β1、TNF-α,分析三者水平变化与肝脏损伤程度的关系。结果:DLC患者血清VEGF、TGF-β1、TNF-α均明显高于健康组,随着肝硬化、肝癌发展,TGF-β1、TNF-α水平逐渐下降(P<0.05,P<0.01);发生慢加亚急性肝衰竭(SACLF)患者VEGF、TNF-α水平高于慢性肝衰竭(CLF)患者(P<0.05);中晚期SACLF患者VEGF、TNF-α高于早期,早中期患者TGF-β1水平低于晚期(P<0.05);死亡患者血清VEGF、TGF-β1水平明显高于病情好转者(P<0.01),TNF-α低于病情好转者(P<0.05)。结论:DLC患者血清VEGF、TGF-β1、TNF-α的水平与疾病的严重程度及预后密切相关,它们在DLC发生发展过程中可能起重要作用。

Objective:To evaluate the significance of serum vascular endothelial growth factor (VEGF),transforming growth factor-β1 (TGF-β1) and tumor necrosis factor-α (TNF-α) in predicting prognosis of patients with decompensated liver cirrhosis (DLC). Methods:Serum VEGF,TGF -β1,and TNF-α were detected in 86 patients with DLC. The correlations between the changes of serum VEGF ,TGF-β1 and TNF-α and the degree of liver injury were analyzed. Results:The serum levels of VEGF,TGF-β1 and TNF-α were all higher than those o...