前臂远端1/3和1/10部位骨密度测量及临床意义

Measurment of bone mineral density at the 1/3 and 1/10 sites at the distal part of forearm and its clinic signification

目的探讨前臂远端1/3和1/10部位骨密度(BMD)的变化规律,为骨质疏松症(OP)的诊断治疗和预防提供科学依据。方法采用双能X线骨密度仪(DEXA)测定1863例健康人前臂远端1/3和1/10部位的BMD,年龄范围20～84岁,按5岁一个年龄组进行统计分析。结果男、女1/3部位骨峰值均在40～44岁年龄组,男、女1/10部位骨峰值分别为30～34岁,25～29岁年龄组。前臂远端1/3和1/10部位BMD及OP患病率也不同;女性45～54岁1/10部位比1/3部位显示更高的OP患病率(P0.01)。结论女性围绝经期测量前臂远端1/10部位BMD可更早的发现OP。同时测定1/3和1/10部位BMD,可较全面反映全身(包括皮质骨和松质骨)的骨量水平,有助于OP的诊断和防治。

Objective To analyse the regularities of bone mineral density of forearm(distal 1/3 and 1/10) and provide scientific basis for the diagnosis,treatment and prevention of OP.Method 1863 normal subjects aged 20 to 84 years was measured for BMD at the 1/3 and 1/10 sites of distal forearm by dual X-ray absorptiometry .They were divided into five year cohorts for analysis.Result Statistical results revealed peak bone density at the 1/3 site was in the 40～44 age cohort for both male and female.Peak bone mineral density at the 1/10 site was in the 30～34 age cohort for male and in the 25～29 age cohort for female.Bone composition was so different at the 1/3 and 1/10 sites at the distal part of forearm that their BMD and the prevalence rate of OP was different also.The prevalence rate of OP at the 1/10 site was higher than at the 1/3 site in female aged 45～54 years(P< 0.01).Conclusion OP may be discovered more early in menopausal women by examining BMD at 1/10 site of distal forearm.Examining BMD simultaneously at 1/3 and 1/10 sites of distal forearm may overall reflect the bone mineral contant of the whole body(including cortical and trabecular bone),and contribute to the diagnosis and treatment of OP.