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基质金属蛋白酶及其抑制剂与肺癌的侵袭和转移 被引量：3

Matrix metalloproteinases and their inhibitors in theinvasion and metastasis of lung cancer
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摘要 基质金属蛋白酶(MMPs)家族是细胞外基质降解过程中的重要酶类,与多种病理过程尤其是肿瘤侵袭和转移有密切关系,因此成为肿瘤治疗的新靶点,本文就MMPs、TIMPs的生物学作用,与肺癌侵袭转移的关系及MMP合成抑制剂的开发研究情况等方面做一综述。 MMPs are critical enzymes for extra-cell matrix disposing process,which closely associate with many pathologic courses,particularly with cancer invasion and metastasis.Because of this,MMPs are becoming new targets for cancer treatment.This study summarized biological function of MMPs and TIMPs,their role in the invasion and metastasis of lung cancer,and recent development of synthetical inhibitor of MMPs.
作者 于学燕 王永刚
机构地区 山东大学 山东大学齐鲁医院
出处 《癌症进展》 2005年第4期374-377,共4页 Oncology Progress
关键词 基质金属蛋白酶 金属蛋白酶抑制剂 肺癌 侵袭 转移 matrix metalloproteinases tissue inhibitor of metalloproteinases lung cancer invasion metastasis
分类号 R734.2 [医药卫生—肿瘤]
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参考文献16

  • 1[1]Liotta LA, Stetler Stevenson WG. Tumor invasion and metastases: An imbalance of positive and negative regulation. Cancer Res, 1991, 51 (Suppl) :5054
  • 2[2]Tsunezuka Y, Kionh H, Takino T, et al. Expression of membrane-type matrix metalloproteinase 1 (MT-MMP) in tumor cells enhances pulmonary metastasis in an experimental metastasis assasy. Cancer Res, 1996, 56 (24) :5678
  • 3方伟岗,李红梅,孔灵玲,牛桂莲,高庆,周可祥,郑杰,吴秉铨.肿瘤侵袭转移过程中基质金属蛋白酶作用机制系列研究[J].北京大学学报（医学版）,2003,35(4):441-443. 被引量：23
  • 4陈洪雷,刁路明,陈德基,李红钢,刘铭球.大鼠肺癌侵袭转移中明胶酶A及其抑制剂的动态表达[J].中华肿瘤杂志,2002,24(2):118-122. 被引量：59
  • 5[5]Farias E, Ranuncolo S, Cresta C, et al. Plasma metaloproteinase activity is enhanced in the ecglobulin fraction of breast and lung cancer patients. Int J Cancer, 2000, 89 (4) :389
  • 6[6]Nawrocki B, Polette M, MarchandV, et al. Expression of matrix metalloproteinases and their inhibitors in hman bronchopulmonary carcinomas: Quantificative and morphological analysis.Int J Cancer, 1997, 72:556
  • 7[7]Nakamura H, Ueno H, Yamashita K, et al. Enhanced production and activation of progelatinase A mediated by membranetype 1 matrix metalloproteinase in human papillary thyroid carcinomas. Cancer Res, 1999, 59 (2) :467
  • 8[8]Kossakowska AE, Huchcroft SA, Urbanski SJ, et al. Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, sporadic colorectal neoplasia,pulmonary carcinomas and malignant non-Hodgkin's lymphomas in human. BrJCancer, 1996, 73 (11) :1401
  • 9[9]Thomas P, Khokha R, Shepherd FA, et al. Differential expression of MMPs and their inhibitors in non-small cell lung cancer. J Pathol, 2000, 190 (2) :150
  • 10[10]Sakaki H, Yukiue H, Moiriyama S, et al. Clinical significance of matrix metalloproteinase-7 and Ets-1 gene expression in patients with lung cancer. J Surg Res, 2001, 101 (2) :242

二级参考文献24

  • 1周可祥,吴秉铨,郑杰,王洁良,由江峰,崔湘琳.TIMP－1基因转染对人肺巨细胞癌细胞系生物学行为的影响[J].中华医学杂志,1994,74(7):402-405. 被引量：13
  • 2田鸿生 刘铭球 等.建立动物肺癌模型的方法学研究：肺叶支气管内灌注致癌质碘油液诱发大白鼠肺癌析新方法[J].肿瘤防治研究,1982,9:2-4.
  • 3[1]Albrechtsen R, Wewer UM, Liotta LA. Basement membranes in human cancer. Pathol Annu,1986,21(Pt 2)∶251-276.
  • 4[2]Kawamata H, Kameyama S, Kawai K, et al. Marked acceleration of the metastatic phenotype of a rat bladder carcinoma cell line by the expression of human gelatinase A. Int J Cancer,1995,63(4)∶568-575.
  • 5[4]Urbanski SJ, Edwards DR, Maitland A, et al. Expression of metalloproteinases and their inhibitors in primary pulmonary carcinomas. Br J Cancer,1992,66(6)∶1188-1194.
  • 6[5]Hofmann UB, Westphal JR, Van Muijen GN, et al. Matrix metalloproteinases in human melanoma. J Invest Dermatol,2000,115(3)∶337-344.
  • 7[6]Ylisirnio S, Hoyhtya M, Turpeenniemi-Hujanen T. Serum matrix metalloproteinases-2, -9 and tissue inhibitors of metalloproteinases-1, -2 in lung cancer--TIMP-1 as a prognostic marker. Anticancer Res,2000,20(2B)∶1311-1316.
  • 8Auerbach R,Lewis R,Shinners B,et al.Angiogenesis assays: a critical overview[J].Clin Chem,2003,49(1):32-40.
  • 9Vihinen P,Kahari VM.Matrix metalloproteinases in cancer: prognostic markers and therapeutic targets [J].Int J Cancer,2002,99(2):157-166.
  • 10Weidner N.Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors[J].Breast Cancer Res Treat,1995,36(2):169-180.

共引文献98

同被引文献37

  • 1马玲,谭德福.竹节参的研究概况[J].时珍国医国药,2005,16(12):1306-1307. 被引量：12
  • 2姜强,张苏展.基质金属蛋白酶及其组织抑制因子与肿瘤研究进展[J].国际肿瘤学杂志,2006,33(1):18-21. 被引量：4
  • 3顿耀艳,袁丁.竹节参化学成分的研究进展[J].时珍国医国药,2006,17(10):1909-1911. 被引量：33
  • 4巫军,易杨华,吴厚铭,贺全山,张诗龙.黑乳海参皂苷nobiliside A的体外抗真菌及抗肿瘤活性[J].中国药理学通报,2007,23(1):139-140. 被引量：27
  • 5袁丁,左锐,张长城.竹节参总皂苷抑制小鼠肿瘤生长的实验研究[J].时珍国医国药,2007,18(2):277-278. 被引量：23
  • 6Simi L, Andreani M, Davini F. Simultaneous measurement of MMP-9 and TIMP-1 mRNA in human non small cell lung cancers by multiplex real time RT-PCR. Lung Cancer,2004,45(2) :171-179.
  • 7Mihaylova Zh, Ludovini V, Gregorg V, et al. Serum level changes of matrix metalloproteinases :2 and 9, vascular endothelial growth factor and epidermal growth factor receptor during platinum-based chemotherapy in advanced non-small cell lung cancer patients. J BUON,2007,12 ( 1 ) : 105-111.
  • 8Pinto CA, Carvalho PE, Antonangelo L. Morphometric evaluation of tumor matrix metalloproteinase 9 predicts survival after surgical resection of adenocarcinoma of the lung. Clin Cancer Res, 2003,9 ( 8 ) : 3098- 3104.
  • 9Zhang, S Y, Yi Y H, Tang, H F, et al. Bioaetive triterpene glycosides from the sea cucumber Holothuria fuscocinerea[J]. J Nat Prod, 2006, 69(10):1492.
  • 10ttu X Q, Wang Y M, Wang J F, et al. Dietary saponins of sea cucumber alleviate orotie acid-induced fatty liver in rats via PPARa and SREBP-1 e signaling[J]. Lipids Health Dis, 2010, 9(1):25. 1.

引证文献3

二级引证文献7

癌症进展
2005年 第4期

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