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Alcoholic liver disease and the gut-liver axis 被引量:54

Alcoholic liver disease and the gut-liver axis
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摘要 Alcoholic liver disease (ALD) is one of the leading causes of liver diseases and liver-related death worldwide. Of the many factors that contribute to the pathogenesis of ALD, gut-derived lipopolysaccharide (LPS) plays a central role in induction of steatosis, inflammation, and fi brosis in the liver. In this review, we discuss the mechanisms by which alcohol contributes to increased gut permeability, the activation of Kupffer cells, and the infl ammatory cascade by LPS. The role of the Toll-like receptor 4 (TLR4) complex in LPS recognition and the importance of the TLR4-induced signaling pathways are evaluated in ALD. Alcoholic liver disease (ALD) is one of the leading causes of liver diseases and liver-related death worldwide. Of the many factors that contribute to the pathogenesis of ALD, gut-derived lipopolysaccharide (LPS) plays a central role in induction of steatosis, inflammation, and fi brosis in the liver. In this review, we discuss the mechanisms by which alcohol contributes to increased gut permeability, the activation of Kupffer cells, and the infl ammatory cascade by LPS. The role of the Toll-like receptor 4...
机构地区 Liver Center
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2010年第11期1321-1329,共9页 世界胃肠病学杂志(英文版)
基金 Supported by NIAAA Grants No. AA017729 Supported by NIAAA Grants No. AA011576
关键词 Kupffer cell Gut permeability MICRORNA Tumor necrosis factor-α ENDOTOXIN Kupffer cell Gut permeability microRNA Tumor necrosis factor-α Endotoxin
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