高血压患者缺血性脑卒中的发生与动态血压的相关性

Correlation between Ischemic Stroke and Ambulatory Blood Pressure Monitoring Indices in Patients with Hypertension

目的探讨动态血压各参数与高血压患者缺血性脑卒中发生的相关关系。方法对450例高血压病患者进行动态血压监测,随访观察3年,根据是否发生缺血性脑卒中分为脑卒中组(IS组,n=82)和无卒中组(NS组,n=354)。用Logistic回归分析确定有无脑卒中者的血压变化。结果 IS组的血压昼夜节律消失百分率、与收缩压(SBP)相关各指标均显著高于NS组(P<0.01),24h平均舒张压(DBP)、日平均DBP、日DBP负荷显著低于NS组(P<0.01);血压昼夜节律消失、与SBP相关各指标与缺血性脑卒中呈正相关关系,24h平均DBP、日平均DBP、日DBP负荷与缺血性脑卒中呈负相关关系。结论血压昼夜节律消失、24h平均DBP、日平均DBP、日DBP负荷降低、与SBP相关各指标对高血压患者发生缺血性脑卒中有相关性。

Objective To investigate the correlation between changes of indices of ambulatory blood pressure monitoring (ABPM) and ischemic stroke in patients with hypertension.Methods 450 patients with hypertension were checked by 24 h ABPM and followed-up for 3 years.According to whether the patients had ischemic stroke,they were divided into the stroke group (IS group,n=82) and the no-stroke group (NS group,n=354).The correlation of stroke and ABPM indices were analyzed by Logistic regression.Results In IS group,the...