摘要
β 1 ,3 葡聚糖对小鼠水浸应激性胃溃疡、乙醇或阿司匹林损伤性胃溃疡、大鼠幽门结扎性胃溃疡和乙酸腐蚀性胃溃疡等有非常显著的预防或治疗作用(p <0 .0 1～ 0 .0 0 1 ) ,而且均有良好的剂量效应关系 .其中小分子β 1 ,3 葡聚糖的抗溃疡作用优于大分子β 1 ,3 葡聚糖 ;β 1 ,3 葡聚糖抗溃疡作用机制与其对胃酸和胃蛋白酶分泌的影响无关 ,而可能与其对胃粘膜的直接接触和对免疫细胞的调节作用有关 .
glucans (βGLN) showed much significant anti-ulcer activities with dose-response relationships for experimental gastric ulcer models induced by the water-restriment stress,ethanol or aspirin,pylorous ligature and acetic acid in mice or rats(P<0.01-0.001). Comparatively,small βGLN was more effective than that of macromolecular βGLN and ranitidine,oral administration was more effective than that of intraperitoneal injection.Results shown that the anti-ulcer mechanisms of βGLNs have no relationship with the secretions of gastic acid and pepsin,maybe act through directly touching to the gastric mucosa and stimulating to the immunocytes.
出处
《山东大学学报（理学版）》
CAS
CSCD
北大核心
2001年第1期107-112,共6页
Journal of Shandong University(Natural Science)
基金
国家九五攻关项目! ( 96 C0 2 0 1 1 0 )
