川崎病患儿血清IL-6、TNF-α与冠状动脉损伤的关系

Changes of the Serum IL-6、TNF-α Levels in Children with Kawasaki Disease

目的:观察川崎病(KD)患儿血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平变化,探讨其与冠状动脉损伤(CALs)的关系。方法:KD患儿入院前常规行心脏超声检查,根据结果分为CALs组(12例)和无CALs组(23例),另选取25例年龄相仿的同期门诊体检健康儿童为正常对照组。采用双抗体夹心酶联免疫吸附实验(ELISA),分别测定正常对照组与KD患儿急性期、治疗后恢复期血清IL-6、TNF-α水平。结果:KD患儿急性期血清IL-6、TNF-α分别为(191.68±114.01)ng/L、(160.73±70.66)ng/L,均高于正常对照组[(87.45±27.37)ng/L、(43.16±28.71)ng/L];治疗后IL-6、TNF-α分别为(95.75±42.08)ng/L、(82.93±38.39)ng/L,治疗前后相比,差异有统计学意义(P<0.01);CALs组IL-6、TNF-α分别为(248.21±147.26)ng/L、(200.89±91.97)ng/L,均高于NCALs组[(162.19±81.19)ng/L、(139.78±46.35)ng/L,P<0.05]。结论:KD患儿急性期炎性因子水平显著增加,且IL-6、TNF-α的水平增高可能与CALs有关,可作为KD患儿CALs的预测指标。

Objective To study the changes of serum levels of interleukin 6(IL-6) and tumor necrosis factor-α(TNF-α) in children with Kawasaki disease(KD) and to explore the relationships with coronary artery lesions(CALs).Methods Twenty-five KD children received cardiac ultrasound examination routinely before admission and were then divided into CALs group(12cases) and non-CALs group(23cases),serum IL-6 and TNF-α were respectively detected by ELISA in both acute phase and recovery phase in 25 KD children and 25 normal children.Results In the KD group of acute phase,the Levels of serum IL-6,TNF-α were(191.68±114.01) ng/L,(160.73±70.66) ng/L,which were higher than those in the nomal group[(87.45±27.37) ng/L,(43.16±28.71) ng/L].In recovery phase after treatment,the levels were(95.75±42.08) ng/L,(82.93±38.39) ng/L,which were significantly different from those in acute phase(P<0.01).Compared with CALs group[(248.21±147.26) ng/L,(200.89±91.97) ng/L],the levels of serum IL-6 and TNF-α were significantly higher in non-CALs group [(162.19±81.19) ng/L,(139.78±46.35) ng/L,P<0.05].Conclusions The levels of inflammatory factors in KD children increase significantly in acute phase.Meanwhile,the high levels of serum IL-6 and TNF-α may be correlated with CALs,which can be used as a CALs predictor in KD children.