摘要
以对苯二酚为原料,在吡啶对甲苯磺酸盐催化下,与3,4-二氢-2H-吡喃一步反应生成对-(四氢-2H-吡喃-2-氧基)苯酚。通过单因素实验确定了反应的适宜条件:以二氯甲烷为溶剂,原料配比n(対苯二酚)∶n(3,4-二氢-2H-吡喃)=2.5∶1,反应温度16±1℃,反应时间3 h。反应的总收率约为19.2%,目标化合物的纯度为99.8%。目标产物的结构通过LC-MS和1H NMR确证。
4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenol was synthesized in 19.2% yield by the reaction of hydroquinone with 3,4-dihydro-2H-pyran catalyzed by PPTS in dichloromethane.The optimum reaction conditions were as follows: the molar ratio of hydroquinone to 3,4-dihydro-2H-pyran 2.5 to 1,reaction temperature 16℃,reaction time 3 h.The structure of the target compound(99.8%) was determined by means of LC-MS and 1H NMR spectra.
出处
《精细化工中间体》
CAS
2012年第6期49-52,共4页
Fine Chemical Intermediates
