SARS患者并发MODS的可能机制及紧急救治对策

Potential mechanism and emergent clinical treatment of multiple organ dysfunction syndrome caused by severe acute respiratory syndrome

根据作者已进行的有关MODS研究和参加抢救SARS患者的临床救治体会 ,并引用国内外公开发表的相关论文和报道 ,探讨了SARS患者并发MODS的可能机制及紧急救治对策 ,提出最终导致SARS患者死亡的并非病毒 ,而是自身免疫系统失衡后的MOF。其治疗的关键应该 :一是要针对新型冠状病毒进行有效的治疗 ;二是要努力调控过度的炎性反应及异常的免疫反应 ;三是要积极治疗内毒素血症 ;四是要对慢性基础疾病进行有效的调控。

Based on our previous clinical and reseach experience, and reference of the published papers, we investigated the potential mechanism and emergent clinical treatment of the multiple organ dysfunction syndrome (MODS) caused by severe acute respiratory syndrome (SARS). It was not the virus but the MODS, associated with immunoimbalance, that led to the death of the patient. Four points during treatment should be paid more attention: 1) effective antivirus therapy; 2) modulating the excessive inflammatory response and imbalanced immune response; 3) emphasizing the treatment of endotoximia; 4) once a shock or MODS occured, corresponding treatment should be applied immediately.