血液透析患者继发性甲状旁腺功能亢进与贫血的关系

Association of secondary hyperparathyroidism and hemoglobin in patients receiving hemodialysis

目的:观察继发性甲状旁腺功能亢进在贫血的关系,探讨血液透析患者甲状旁腺素与血红蛋白水平的关系。方法:回顾性分析2010年3月至2012年12月广州医科大学第一附属医院收治的59例血液透析患者的资料,收取血液标本,检测血尿素氮(3un)、肌酐、血红蛋白(Hb)、铁蛋白、全段甲状旁腺素(iPTH)。结果:Bun、肌酐、Hb、铁蛋白、iPTH分别为(26.3+5.5)mol/L、(834.2±125.4)μmo1/L、(73.1±23.1)g/L、(665.3±552.2)ng/mL、(548.8±452.5)pg/m L;iPTH对Hb有显著性影响(x^2=27.142,P<0.001)。iPTH与Hb为负相关关系(r=0.565);iPTH与铁蛋白呈正相关关系(r=0.070)。结论:血透患者贫血的发生与甲状旁腺功能亢进有关,有效控制SPHT有助贫血的治疗。

Objective:To investigate the effects of secondary hyperparathyroidism(SHPT) as a cause of anemia and the relationship of intact parathyroid hormone(iPTH) and hemoglobin(Hb) levels in patients receiving hemodialysis(HD).Methods:Between March 2010 and December 2012,we did a retrospective analysis on the clinical profiles of 59 patients receiving hemodialysis from The First Affiliated Hospital of Guangzhou Medical University.Serum samples were collected for the measurement of urea,creatinine,Hb,ferritin and iPTH levels.Results:The levels of serum urea,creatinine,Hb,ferritin and intact PTH were(26.33±5.54)mol/L,(834.23±125.44) μmol/L,(73.1±23.1)g/L,(665.3±552.2)ng/ml and(548.78±452.54)pg/ml respectively.The level of iPTH had a considerable impact on the Hb(x^2 = 27.142,P<0.001).The iPTH was negatively correlated with Hb(r=0.565,P<0.05) And positively correlated with ferritin(r=0.070,P<0.05).Conclusion:Secondary hyperparathyroidism(SHPT) may be a cause of anemia in patients receiving hemodialysis and an effective control of parathyroid hormone hypersecretion may be associated with alleviation of anemia.