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Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin 被引量:5

Endogenous enkephalin does not contribute to the cerebral anti-hyperalgesic action of gabapentin
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摘要 The aim of this study was to investigate the role of endogenous enkephalin in the cerebral antihyperalgesic action of gabapentin.Neuropathic pain models and antihyperalgesic effect of gabapentin were confirmed by the presentation and changes of mechanical allodynia and thermal hyperalgesia of operated mouse hind paws.The results suggested that endogenous enkephalin may not be involved in the antihyperalgesic effect of gabapentin. The aim of this study was to investigate the role of endogenous enkephalin in the cerebral antihyperalgesic action of gabapentin.Neuropathic pain models and antihyperalgesic effect of gabapentin were confirmed by the presentation and changes of mechanical allodynia and thermal hyperalgesia of operated mouse hind paws.The results suggested that endogenous enkephalin may not be involved in the antihyperalgesic effect of gabapentin.
出处 《Science China(Life Sciences)》 SCIE CAS 2010年第12期1428-1432,共5页 中国科学(生命科学英文版)
关键词 neuropathic pain GABAPENTIN ENKEPHALIN cerebral cortex neuropathic pain gabapentin enkephalin cerebral cortex
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