期刊文献+

A meta-analysis of oxidative stress markers in schizophrenia 被引量:32

A meta-analysis of oxidative stress markers in schizophrenia
原文传递
导出
摘要 Oxidative stress has been identified as a possible element in the neuropathological processes of schizophrenia(SCZ).Alteration of oxidative stress markers has been reported in SCZ studies,but with inconsistent results.To evaluate the risk of oxidative stress to schizophrenia,a meta-analysis was conducted,including five markers of oxidative stress [thiobarbituric reactive substances(TBARS),nitric oxide(NO),catalase(CAT),glutathione peroxidase(GP) and superoxide dismutase(SOD)] in SCZ patients versus healthy controls.This study showed that TBARS and NO significantly increased in SCZ,while SOD activity significantly decreased in the disorganized type of SCZ patients.No significant effect size was found for the activities of GP and CAT in SCZ patients(P】0.05).Egger’s regression test observed no significant publication bias across the oxidative stress markers,but found high heterogeneities in all the 5 markers.The subgroup analysis suggested that the ethnicity,sample size of patients and sample sources may contribute to the heterogeneity of the results for TBARS,NO and SOD.The result further demonstrated the involvement of oxidative stress in the pathophysiology of schizophrenia. Oxidative stress has been identified as a possible element in the neuropathological processes of schizophrenia(SCZ).Alteration of oxidative stress markers has been reported in SCZ studies,but with inconsistent results.To evaluate the risk of oxidative stress to schizophrenia,a meta-analysis was conducted,including five markers of oxidative stress [thiobarbituric reactive substances(TBARS),nitric oxide(NO),catalase(CAT),glutathione peroxidase(GP) and superoxide dismutase(SOD)] in SCZ patients versus healthy controls.This study showed that TBARS and NO significantly increased in SCZ,while SOD activity significantly decreased in the disorganized type of SCZ patients.No significant effect size was found for the activities of GP and CAT in SCZ patients(P>0.05).Egger’s regression test observed no significant publication bias across the oxidative stress markers,but found high heterogeneities in all the 5 markers.The subgroup analysis suggested that the ethnicity,sample size of patients and sample sources may contribute to the heterogeneity of the results for TBARS,NO and SOD.The result further demonstrated the involvement of oxidative stress in the pathophysiology of schizophrenia.
出处 《Science China(Life Sciences)》 SCIE CAS 2010年第1期112-124,共13页 中国科学(生命科学英文版)
基金 supported by the National Basic Research Program of China (Grant Nos 2006CB910600, 2007CB947300, and 2010CB529600) the Shanghai Leading Academic Discipline Project (Grant No B205) the Shanghai Municipality Science & Technology Commission (Grant Nos 05JC14090 and 07DJ14005) the Chinese Nutrition Society (Grant No 05015) the Knowledge Innovation Program of the Chinese Academy of Sciences (Grant No KSCX2-YW-R-01) the National Natural Science Foundation of China (Grant No 30700203) and a NARSAD Young Investigator Award to ZZ
关键词 SCHIZOPHRENIA oxidative stress META-ANALYSIS LIPID PEROXIDATION NITRIC oxide antioxidant ENZYMES schizophrenia oxidative stress meta-analysis lipid peroxidation nitric oxide antioxidant enzymes
  • 相关文献

参考文献64

  • 1Assen Jablensky.Epidemiology of schizophrenia: the global burden of disease and disability[J]. European Archives of Psychiatry and Clinical Neurosciences . 2000 (6)
  • 2Bazan N G,Marcheselli V L,Cole-Edwards K.Brain response to injury and neurodegeneration: Endogenous neuroprotective signaling. Annals of the New York Academy of Sciences . 2005
  • 3Maral J K,Puget K,Michelson A M.Comparative study of superox-ide dismut.ase,catalase and glutathione peroxidase levels in erythro-cyte8of different animals. Biochem Biophys Ree Commum . 1977
  • 4Barthwal M K,Srivastava N,Shukla R,et al.Polymorphonuclear leukocyte nitrite content and antioxidant enzymes in Parkinson’s disease patients. Acta Neurologica Scandinavica . 1999
  • 5Cannon TD,Kaprio J,Lonnqvist J,et al.The genetic epidemiology of schizophrenia in a Finnish twin cohort: A population-based modeling study. Archives of General Psychiatry . 1998
  • 6Furchgott R F,Zawadzki J V.The obligatory role of the endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature . 1980
  • 7Abdalla D S P,Monteriro H P,Oliveira J A C,et al.Activities of superoxide dismutase and glutathione peroxidase in schizophrenic and manic-depressive patients. Clinical Chemistry . 1986
  • 8DerSimonian R,Laird N.Meta-analysis in clinical trials. Controlled Clinical Trials . 1986
  • 9Egger M,Davey Smith G,Schneider M,et al.Bias in meta-analysis detected by a simple, graphical test. British Medical Journal . 1997
  • 10Church DF,Pryor WA.Free-radical chemistry of cigarette smoke and its toxicological implications. Journal of Environmental Health . 1985

同被引文献280

引证文献32

二级引证文献286

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部