原发性高血压发病机制及治疗探讨

The Pathogenesis and Treatment of Essential Hypertension

目的:探讨原发性高血压的发病机制及治疗。方法:从人体为一统一的有机整体出发,从辨证的角度,通过对机体与损伤因子之间相互作用所发生的损伤效应及机体的去损伤调节的分析,探讨高血压病可能的发生机制。并以此为基础,将治疗高血压的药物按改善靶器官功能及调节神经内分泌因子进行分类,提出合理的治疗方案。结果:原发性高血压与内因的调控及外因的诱导密切相关。任何损伤因子的存在必将引起机体的去损伤效应而使效应器官达到新的平衡。由于个体的差异及损伤因子性质的不同,对损伤因子过于敏感及调节能力差的个体易于出现调节紊乱,在神经内分泌因子的参与下导致高血压的形成。因在高血压不同的阶段机体相应靶器官紊乱程度不同,故治疗方案视相应靶器官的功能状况而存在差异。结论:原发性高血压与基因表达的时间依从性及相关基因的诱导表达密切相关。高血压发病初期,应以改善靶器官自身功能的药物为主,辅以小剂量调节神经内分泌的药物为佳;对靶器官已损伤者,调节神经内分泌的药物为必需,联用改善靶器官功能的药物作为基础,利于靶器官结构及功能的恢复。

Objective:To investigate the pathogenesis and treatment of essential hypertension.Methods: Take from the human body as a unified whole,to analysis the damaging effect and the adjusting of removing damage from the body caused by the interactions between the body and damage factor from the dialectical angle to investigate the pathogenesis of essential hypertension.Based on these,to classify the drug treatment for hypertension according to improve target organ function and the adjustment nerve internal secretion factor,proposing the reasonable treatment plan.Results: Essential hypertension is closely related with internal controlled and external induced.Any damage factor existence will certainly to cause the effect of removing damage by the organism to enable the effect organ to achieve the new balance.For the difference of the individual and the damage factor,to be sensitive to damages factor and the low of the adjustment ability individual easy to have the adjustment disorder,causes hypertension in under the nerve internal secretion factor participation the formation.Because of in different stage organism corresponding organ degree of turbulence different,therefore the treatment plan regards the corresponding target organ the function condition to have the difference.Conclusion:Essential hypertension is closely related with time compliance of gene expression and induction of genes;in initial period,the medicine take to improve target organ own function,auxiliary small dosage adjustment nerve internal secretion medicine as good;to target organ already damage,adjustment nerve internal secretion medicine for essential,the association with the improvement target organ function medicine underlie,favors the target organ structure and the function restoration.