新诊断2型糖尿病病人脂代谢紊乱状态与胰岛素抵抗及胰岛素分泌缺陷

The Impact of Dyslipidaemia on insulin resistance and insulin secretion in newly diagnosed type 2 diabetic patients

目的 观察新诊断的 2型糖尿病病人脂代谢紊乱状态与胰岛素抵抗及胰岛素分泌缺陷的关系。方法 14 3例新诊断的 2型糖尿病病人 ,根据美国ATPIII标准分为血脂正常组 ,高甘油三酯组、高胆固醇组、混合性高脂组 ,应用稳态模型评估法评价胰岛素敏感性及胰岛B细胞功能 ,探讨各种类型的脂代谢紊乱与胰岛素抵抗及胰岛素分泌缺陷的关系。结果 新诊断的 2型糖尿病病人血脂紊乱发生率为 5 6.6% ,高甘油三酯组的HOMA IR较正常组显著升高。各组HOMA β无显著差别。结论 新诊断的 2型糖尿病病人脂代谢紊乱类型以高TC/LDL最常见 ,但高TG者的胰岛素抵抗程度更为严重。

Objective To investigate the relationship of dyslipidaemia and insulin resistance and secretion.Methods 143 newly diagnosed type 2 diabetic patients were divided into normal and dyslipidaemic groups.The dyslipidaemia group included 3 subgroups as follows:subgroup I with high triglycerides, subgroup II with high cholesterol,subgroup III with both high triglycerides and high cholesterol. Homeostasis model assessment (HOMA) was applied to estimate insulin resistance ( IR) and pancreatic islet β-cell function.Results Incidence of dyslipidaemia in newly diagnosed type 2 diabetic patients is 56.6%. HOMA-IR was increased in the subgroups with high triglycerides.HOMA-βwas similar in all groups.Conclusion high cholesterol was most common in newly diagnosed type 2 diabetic patients,but insulin resistance was more severe in the subject with high triglycerides.