非酒精性脂肪性肝炎116例内科综合治疗观察

The combinative treatment with internal medicine on non-alcoholic steatohepatitis

目的 观察以饮食控制结合降脂药物、抗氧化剂的内科综合疗法治疗非酒精性脂肪性肝炎的疗效 ,以期为非酒精性脂肪性肝炎的临床治疗提供一些实际经验。方法 将 116例非酒精性脂肪性肝炎患者随机分为对照组和治疗组。对照组给予饮食控制 ,同时口服水飞蓟素和辛伐他汀 ,疗程为 3个月 ;治疗组在对照组的基础上加用还原性谷胱甘肽静脉点滴 ,疗程为 1个月。结果 治疗组总有效率为 87.5 0 % ,对照组总有效率为 61.66%。治疗组总有效率显著高于对照组 (P<0 .0 5 )。结论 非酒精性脂肪性肝炎的治疗应以内科综合治疗为宜。抗氧化剂还原性谷胱甘肽在非酒精性脂肪性肝炎的内科综合治疗中有重要作用。

Objective To investigate the effect of the combinative treatment including diet control, reducing lipemia and oxidation retarder on non-alcoholic steatohepatitis.Methods One hundred and sixteen non-alcoholic steatohepatitis patients were divided into 2 groups randomly.Control group:diet control combining with silymarin,simvastatin for 3 months;Treatment group:besides above treatment,intravenous drip reduced glutathione was added for 1 month.Results The general effective rate in treatment group (87.50%) was markedly higher than that in control group (61.66%).Conclusion The oxidation retarder reduced glutathione plays an important role in combinative treatment on non-alcoholic steatohepatitis.