妊高征孕妇血浆硒水平与红细胞内谷胱甘肽过氧化物酶的关系

The Relationship between the Serum Selenium Concentration and Glutathione Peroxidase in Red Blood Cell in Patients with Pregnancy Induced Hypertension

目的探讨妊高征孕妇血浆中硒浓度与红细胞内谷胱甘肽过氧化物酶的关系。方法应用原子吸收法及细胞化学发光检测法测定49例妊高征孕妇(妊高征组)和34例正常孕妇(正常妊娠组)血浆中硒的水平及红细胞内谷胱甘肽过氧化物酶(GSH-PX)的浓度。结果妊高征组血浆硒水平及红细胞内 GSH-PX 浓度明显低于正常妊娠组,而且孕妇血浆中硒水平与红细胞内 GSH-PX 浓度之间呈直线回归关系,即随着血浆硒水平的升高,红细胞内 GSH-PX 也升高。结论孕妇血浆硒水平与红细胞内 GSH-PX 浓度与妊高征的发病有一定的关系。

Objective To study the relationship between the serum selenium(Se) concentra- tion and glutathione peroxidase(GSH-PX) levels in red blood cell in patients with pregnancy induced hypertension(PIH).Methods The serum Se concentration was measured by atomic absorbability assay and the GSH-PX levels were measured by cellular chemiluminescence assay.49 cases of PIH and 34 normal pregnant women were measured for serum Se concentration and GSH-PX levels in red blood cell from April,1994 to December,1994.Results The serum Se concentration and GSH-PX levels in red blood cell is different betwen PIH and control group.Compared serum Se concentration and GSH-PX levels were significant lower in the PIH patients than in the control subjects (P<0.01). Furthermore,there were the relationship of linear regression between the serum Se concentration and GSH-PX levels in red blood cell in the pregnant women (P<0.01).Conclusion THe PIH patients had lower serum Se concentration and GSH-PX levels in red blood cell.Thus,lower serum Se concen- tration and GSH-PX levels in red blood cell may contribute to the pathogenesis of PIH.