奥氮平治疗对精神分裂症患者生活质量的影响

Effect of olanzapine on the quality of life of patients with schizophrenia

目的:探讨奥氮平治疗精神分裂症患者对其生活质量的影响。方法:选择30例青壮年精神分裂症患者作为研究对象,所有患者均符合中国精神疾病分类与诊断标准第3版(CCMD-3)精神分裂症诊断标准,使用单一奥氮平治疗精神分裂症中,疗程11个月。观察其疗效与副作用,采用世界卫生组织简明生活质量评定量表(WHOQOL-BREF)评定精神分裂症患者使用奥氮平治疗前后的生活质量,分析量表中各领域和各方面的计分。结果:奥氮平的有效率达87%,锥体外系反应少。经治疗11个月,精神分裂症患者身体健康、心理健康、社会关系和环境因素等4个领域计分均有显著改善,分别为69.17±5.67,91.39±12.18,92.78±12.33,91.56±11.49,与治疗前比较,差异均有显著性意义(t=19.64,14.16,20.56,20.55;P均<0.01),且存在一定的时效关系,评定患者量表各领域分均显著增高。但在治疗2个月时患者对医疗的依赖仍然未得到明显改善,与治疗前相比,差异无显著性意义(t=1.98,P>0.05);用药后1个月后患者仍然认为其生活中存在信息匮乏的情况,与治疗前相比,差异无显著性意义(t=1.77,P>0.05)。结论:奥氮平治疗对改善精神分裂症患者的生活质量有积极作用。

AIM:To investigate the effect of olanzapine on the quality of life(QOL) on patients with schizophrenia. METHODS:A total of 30 adult patients with schizophrenia were selected in this study.All the cases were in accordance with the third revision of Chinese Classification of Mental Disoralers(CCMD 3).During the whole 11 month therapeutic course,only olanzapine was administered.Besides the effects and adverse effects of olanzapine,WHOQOL BREF measuring scale was used to evaluate the patients' QQL before and after administration of olanzapine,by means of analyzing the scores in every domain and facet. RESULTS:The efficiency of olanzapine was 87%,rarely with extra pyramidal side effects.After treated with olanzapine for 11 months, physical health,psychological health,social relationship,and environment of patients with schizophrenia were all significantly improved:69.17±5.67, 91.39±12.18,92.78±12.33,91.56±11.49,as compared with those before treatment,which indicated significant difference(t=19.64,14.16, 20.56,20.55;all P< 0.01).This improvement showed certain time effect relationship.Scores of every domain were all significantly increased by evaluating scale of patients.But compared with the situation before treatment, it was showed that the patients' relied on medication had not improved significantly 2 months after treatment,which indicated no significant difference (t=1.98,P >0.05);and had some complaint about information lackage in 1 month,which indicated no significant difference(t=1.77,P >0.05). CONCLUSION:Olanzapine has positive effects on QOL of patients with schizophrenia.