γ干扰素释放试验在幼儿隐性结核感染诊断中的临床价值分析

Clinical application of interferon gamma release assays for diagnosis of latent tuberculosis infection in children

目的：探讨γ干扰素试验在幼儿隐性结核感染诊断中的临床价值。方法选取2012年1月～2013年3月来十堰市太和医院诊治的疑似隐性结核感染的患者33例和活动性结核感染患者35例作为观擦组，另外选取同一时期来十堰市太和医院体检的30名健康儿童作为对照组，分别对以上3组进行痰涂片分析、结核菌素皮肤试验（tuberculin skin test，TST）和γ干扰素释放试验（interferon gamma release assay，IGRA），比较不同方法阳性率。结果在疑似隐性结核感组中，IGRA的检测结果显著高于TST和痰涂片分析（P＜0.05）；在活动性结核感染组中，IGRA的检测结果显著高于TST和痰涂片分析（P＜0.05）；在健康对照组中，TST的检测结果高于IGRA，这与研究对象曾接种过卡介苗有关。IGRA在疑似隐性结核感组和活动性结核感染组检测阳性率分析，P＞0.05。结论γ干扰素释放试验可作为隐性结核感染诊断的方法之一。

Objective To explore the clinical value of interferon gamma release assays in early childhood diagnosis of latent tuberculosis infection.Methods 33 patients with suspected latent tuberculosis infection and 35 patients with active tuberculosis infection in our hospital from January 2012 to March 2013 were selected.During the same period selected 30 healthy children as a control group.Respectively were given sputum smear analysis,tuberculin skin test (TST)and vinterferon release assay (IGRA).Compare the positive rate of different methods. Results In suspected latent tuberculosis group,IGRA test results were significantly higher than TST and sputum smear method(P<0.05);in active tuberculosis infection group, IGRA test results were significantly higher than TST and sputum smear(P<0.05 );in healthy control group,TST test results were higher than the IGRA,it is because of patients had been vaccinated with BCG.Conclusion IGRA can be used as one way to diagnosis the latent tuberculosis infection.