慢性阻塞性肺疾病合并重症感染患者抗生素降阶梯治疗疗效观察

Efficacy of chronic obstructive pulmonary disease with severe infection in patients with antibiotic de-escalation therapy

目的探讨采用抗生素降阶梯治疗对慢性阻塞性肺疾病合并重症肺炎的疗效。方法 94例慢性阻塞性肺疾病合并重症感染患者随机分为实验组和对照组。实验组采用降阶梯治疗,对照组采用常规抗生素治疗,比较两组疗效。结果降阶梯的治疗组改善临床症状、体征、住院天数、中性粒细胞百分比、CRP均低于常规抗生素治疗的对照组,差异有统计学意义(P<0.05),动脉氧分压、氧饱和度显著上升,差异有统计学意义(P<0.05)。结论抗生素降阶梯治疗减少不适当抗生素治疗的比例,缩短治疗时间,改善临床症状,提高慢性阻塞性肺疾病合并重症肺炎的救治效果,同时避免抗生素滥用和医疗资源浪费。

Objective To investigate the antibiotic de-escalation treatment efficacy of chronic obstructive pulmonary disease with severe pneumonia. Methods 94 cases of chronic obstructive pulmonary disease complicated by severe infections were randomly divided into experimental and control groups. The experimental group escalation therapy, the control group with conventional antibiotic treatment, after treatment. Results De-escalation of the treatment group improved the clinical symptoms, signs, length of stay, percentage of neutrophils, CRP were lower than the control group of conventional antibiotic therapy, the difference was statistically significant(P <0.05), arterial partial pressure of oxygen, oxygen saturation increased significantly, the difference was statistically significant(P <0.05). Conclusion The antibiotic escalation therapy to reduce the proportion of inappropriate antibiotic therapy and shorten treatment time and improve clinical symptoms, the treatment effect of chronic obstructive pulmonary disease with severe pneumonia, while avoiding antibiotic misuse and waste of medical resources.