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Response letter regarding the interpretation of gene expression data

Response letter regarding the interpretation of gene expression data
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摘要 This is a response letter to Verna E's comments regarding our previous manuscript published last year in the World Journal of Gastroenterology entitled "Relationship between LYVE-1,VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer",which evaluated the relationship between these expression levels and clinicopathological parameters(Ozmen F et al,World J Gastroenterology 2011;17:3220-3228).The mean values for lymphatic vessel endothelial hyaluronan receptor-1,CD44 and vascular endothelial growth factor receptor-3 expression(represented as 2-Ct) were 1.13,1.24 and 1.17,respectively,suggesting an increase in gene expression in tumor tissue compared to normal tissue.Despite the increase in gene expression in the cancer tissues(2-Ct > 1),only some of the results reached statistical significance,which was thoroughly discussed in our paper.In the present letter,we report that his comments are flawed and result in confusion.Therefore,we herein provide more explanation regarding gene expression in gastric cancer.We hope that this letter will address Verna E's misunderstandings. This is a response letter to Verna E’s comments regarding our previous manuscript published last year in the World Journal of Gastroenterology entitled “Relationship between LYVE-1, VEGFR-3 and CD44 gene expressions and lymphatic metastasis in gastric cancer”, which evaluated the relationship between these expression levels and clinicopathological parameters (Ozmen F et al, World J Gastroenterology 2011; 17: 3220-3228). The mean values for lymphatic vessel endothelial hyaluronan receptor-1, CD44 and vascular endothelial growth factor receptor-3 expression (represented as 2-ΔΔCt) were 1.13, 1.24 and 1.17, respectively, suggesting an increase in gene expression in tumor tissue compared to normal tissue. Despite the increase in gene expression in the cancer tissues (2-ΔΔCt > 1), only some of the results reached statistical significance, which was thoroughly discussed in our paper. In the present letter, we report that his comments are flawed and result in confusion. Therefore, we herein provide more explanation regarding gene expression in gastric cancer. We hope that this letter will address Verna E’s misunderstandings.
作者 Fusun Ozmen
出处 《World Journal of Gastroenterology》 SCIE CAS 2013年第10期1669-1670,共2页 世界胃肠病学杂志(英文版)
关键词 GASTRIC cancer LYMPHATIC metastasis LYMPHATIC vessel ENDOTHELIAL HYALURONAN receptor-1 Vascular ENDOTHELIAL growth factor receptor-3 CD44 Gastric cancer Lymphatic metastasis Lymphatic vessel endothelial hyaluronan receptor-1 Vascular endothelial growth factor receptor-3 CD44
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