小半夏加茯苓汤治疗化疗致迟发性呕吐的临床疗效观察

Clinical effect of Poria cocos plus Little Pinellia ternata decoction in treating chemotherapy induced delayed nausea and vomiting

[目的]评价小半夏加茯苓汤治疗化疗迟发性呕吐的有效性和安全性。[方法]2011年3月—2012年5月对91例符合入选标准的患者进行随机分组、平行对照研究。治疗组(小半夏加茯苓汤治疗)46例,对照组(甲氧氯普安治疗)45例,连续用药3 d,比较两组疗效。严密观察和记录治疗过程中的不良事件,进行安全性评价。[结果]治疗组止呕有效率较对照组组间差异明显,P<0.05。两组均未出现不良事件,安全性较好。[结论]小半夏加茯苓汤治疗化疗迟发性呕吐有较好的疗效。

[Objective] To evaluate the efficacy and safety of Poria cocos plus Little Pinellia ternata decoction in the treatment of delayed chemotherapy induced nausea and vomiting.[Methods] From March,2011 to May,2012,91 patients with delayed chemotherapy induced nausea and vomiting were randomized into two groups for parallel-controlled study.The treatment group(46 patients) was treated by Poria cocos plus Little Pinellia ternata decoction for 3 days,while the control group(45 patients) by metoclopramide.We compared the curative effect of two groups.The occurrences of adverse events were evaluated as well.[Results] There had obvious differences in curative effect between treatment group and control group.In both groups no adverse events were found.[Conclusion] Poria cocos plus Little Pinellia ternata decoction has good curative effect in the treatment of delayed chemotherapy induced nausea and vomiting.