依托考昔在骨关节炎治疗中的效果与安全性分析

Efficacy and safety analysis of etoricoxib in the treatment of osteoarthritis

目的分析依托考昔在骨关节炎治疗的效果与安全性。方法选取50例2013年1月~2014年4月来华中科技大学同济医学院附属普爱医院治疗骨关节炎的患者,按照随机数字表的方法,将其随机分成对照组与试验组,每组各25例患者。对照组的患者使用常规的诊治方法,试验组的患者使用依托考昔的诊治方法,将试验组与对照组2组患者治疗的不良反应率,以及服药前,服药后5 h,3 d,5 d,7 d关节疼痛程度进行详细的对比分析。结果经过治疗后发现,试验组和对照组2组患者,在服药后5 h以及3d疼痛比较发现,2者没有显著差异,不具有统计学意义;试验组患者在服药5 d以及7 d后的疼痛程度分别为(0.62±0.75),(0.62±0.75),对照组患者在服药5 d以及7 d后的疼痛程度分别为(0.82±1.11),(0.25±0.52),比较2组间差异显著,具有统计学意义(P<0.05)。另外,试验组患者中有3例患者出现不良反应,不良反应率为12%,对照组患者中有4例患者出现不良反应,不良反应率为16%,2者没有显著差异,没有统计学意义。结论依托考昔具有副作用少,吸收好,起效快,以及消炎镇痛持续时间较长的特点。

Objective To analyze the effect of etoricoxib in the treatment of osteoarthritis and security. Methods 50 osteoarthritis patients were selected in January 2013 to April 2014 from the Puai Hospital according to the method of random number table,and they were randomly divided into control group and experimental group,each group had 25 patients. The control group were treated with the conventional method,and the test group of patients were treated with etoricoxib,The adverse reaction and,pain degree before treatment and after taking medicine 5 h,3 d,5 d,7 d,were analysed. Results After treatment,it found that the testpain degree group and control group after taking medicine 3 d and 5 h with comparison,were not significantly different,but the patients of test group for 5d and 7 d pain extent were( 0. 62 ± 0. 75),( 0. 62 ± 0. 75),the control group were( 0. 82 ±1. 11),( 0. 25 ± 0. 52),with statistical significance( P < 0. 05). In addition,3 patients in the test group had adverse reactions,and adverse reactions was12%; 4 patients in the control group had adverse reactions, and adverse reactions was 16%, there were no significant differences.Conclusion Etoricoxib has few side effects,with good absorption,rapid onset and long duration of anti-inflammatory characteristics.