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富含谷氨酰胺的全胃肠外营养对重型颅脑损伤患者肺部感染几率的影响 被引量：2

The influence of glutamine-enriched total parenteral nutrition on morbidity rate of lung infection in patients with severe craniocerebral injury
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摘要 一般认为谷氨酰胺是一种非必需氨基酸.然而,最近的一些研究为谷氨酰胺可能成为炎症状态如感染和创伤时的"条件性必需氨基酸"提供了证据[1-2].
作者 赵灵 管向东 程燕子 楚磊 曾凡
机构地区 [ 中山医科大学第一附属医院外科ICU
出处 《中华危重病急救医学》 CAS CSCD 北大核心 2008年第11期-,共2页 Chinese Critical Care Medicine
关键词 谷氨酰胺 颅脑损伤 重型 感染 全胃肠外营养
分类号 R9 [医药卫生—药学]
  • 相关文献

参考文献15

  • 1Ali S,Roberts PR. Nutrients with immune-modulating effects:what role-should they play in the intensive care unit[J].Current Opinion in Anaesthesiology,2006,(02):132-139.doi:10.1097/01.aco.0000192800.95172.47.
  • 2Rogeri PS,Costa Rosa LF. Plasma glutamine concentration in spinal cord injured patients[J].Life Sciences,2005,(19):2351-2360.doi:10.1016/j.lfs.2004.09.050.
  • 3王新颖,李维勤,李宁,黎介寿.谷氨酰胺缺乏对危重病患者免疫及脏器功能的影响[J].中国危重病急救医学,2006,18(3):143-145. 被引量：66
  • 4Boelens PG,Houdijk AP,Fonk JC. Glutamine-enriched enteral nutrition increases in vitro interferongamma production but dose not influence the in vivo specific antibody response to KLH after severe trauma,a prospective,double blind,randomized clinical study[J].Clinical Nutrition,2004,(03):391-400.doi:10.1016/j.clnu.2003.09.002.
  • 5Boelens PG,Fonk JC,Houdijk AP. Primary immune response to keyhole limpet haemocyanin following trauma in relation to low plasma glutamine[J].Clinical and Experimental Immunology,2004,(02):356-364.doi:10.1111/j.1365-2249.2004.02447.x.
  • 6Ziegler TR,Daignauh NM. Glutamine regulation of human immune cell function[J].Nutrition,2000,(06):458-459.doi:10.1016/S0899-9007(00)00359-2.
  • 7Eaves-Pyles T,Wong HR,Alexander JW. Sodium arsenite induces the stress response in the gut and decreases bacterial translocation in a burned mouse model with gut-derived sepsis[J].Shock,2000,(04):314-319.doi:10.1097/00024382-200004000-00010.
  • 8Oehler R,Pusch E,Dungel P. Glutamine depletion impairs cellular stress response in human leucocytes[J].British Journal of Nutrition,2002,(z1):S17-S21.doi:10.1079/BJN2001453.
  • 9蔡国龙,严静,虞意华,张召才,龚仕金,戴海文,陈进.谷氨酰胺和生长激素强化营养对老年危重病患者免疫调理的影响[J].中国危重病急救医学,2006,18(10):595-598. 被引量：14
  • 10Griffiths RD,Jones C,Palmer TE. Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition[J].Nutrition,1997,(03):295-302.

二级参考文献34

  • 1王新颖,李维勤,李宁,黎介寿.谷氨酰胺缺乏对危重病患者免疫及脏器功能的影响[J].中国危重病急救医学,2006,18(3):143-145. 被引量：66
  • 2刘放南,盛学勤,陈永明.高效液相色谱法测定超滤后血浆中的谷氨酰胺[J].生物化学与生物物理进展,1996,23(5):475-477. 被引量：18
  • 3Splittler A,Winkler S,Gotzinger P,et al.Influence of glutamine on the phenotype and function of human monocytes[J].Blood,1995,86:1564-1569.
  • 4Oehler R,Pusch E,Dungel P,et al.Glutamine depletion impairs cellular stress response in human leucocytes[J].Br J Nutr,2002,87:S1-6.
  • 5Spittler A,Sautner T,Gornikiewicz A,et al.Postoperative glycyl-glutamine infusion reduces immunosuppression:partial prevention of the surgery decrease in HLA-DR expression on monocytes[J].Clin Nutr,2001,20:3742.
  • 6Hulst R R W J,van der Meyenfeldt M F,von Deutz N E P,et al.Glutamine extraction by the gut is reduced in depleted patients with gastrointestinal cancer[J].Ann Surg,1997,225:112-121.
  • 7Umpleby A M,Carroll P V,Russell-Jones D L,et al.Glutamine supplementation and GH/IGF-1 treatment in critically ill patients:effects on glutamine metabolism and protein balance[J].Nutrition,2002,18:127-129.
  • 8Oudemans-van Straaten H M,Bosman R J,Treskes M,et al.Plasma glutamine depletion and patient outcome in acute ICU admissions[J].Intensive Care Med,2001,27:84-90.
  • 9Griffiths R D,Jones C,Allan Palmer T E,et al.Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition[J].Nutrition,1997,13:295-302.
  • 10Exner R,Tamandl D,Goetzinger P,et al.Perioperative GLY-GLN infusion diminishes the surgery-induced period of immunosuppression[J].Ann Surg,2002,237:110-115.

共引文献96

同被引文献7

引证文献2

二级引证文献14

中华危重病急救医学
2008年 第11期

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