CS-PMA30水凝胶对考马斯亮蓝控释性能的研究

The Controlled-Release Properties of Chitosan Hydrogels with Phosphorylcholine Groups

壳聚糖(CS)是自然界中唯一的聚阳离子碱性多糖,具有良好的组织相容性、生物可降解性、无毒、无刺激、pH响应性等优点,因而在药物控释领域的具有潜在的应用价值。将聚阳离子壳聚糖与聚阴离子甲基丙烯酰氧乙基磷酰胆碱-甲基丙烯酸二元共聚物(poly(MPC-co-MA),PMA30)进行静电复合,制备CS-PMA30聚离子水凝胶。以考马斯亮蓝为模型药物,对CS-PMA30水凝胶的控释性能进行研究。结果表明,该CS-PMA30体系是通过静电作用形成的物理交联水凝胶,具有pH响应性,有望在药物控释、组织工程等领域得到广泛应用。

Chitosan(CS)is a polycationic biopolymer,one of the most abundant natural polysaccharides in nature.With numerous desirable properties such as good biocompatibility,biodegradability,pH response,non-toxicity and no stimulation to human tissues,chitosan has emerged as a promising drug delivery.The PMA30 was synthesized by free radical polymerization of 2-methacryloyloxyethyl phosphorylcholine(MPC)and methacrylic acid(MA)with the MPC monomer molar percentage in the feed of 30%.The CS-PMA30 polyelectrolyte hydrogel was prepared through electrostatic interaction between chitosan polycation and PMA30 polyanions.In vitro drug release of coomassie brilliant blue G-250 from the CS-PMA30 hydrogel was determined by dialysis method.The results suggest that the CS-PMA30 hydrogel with phosphorylcholine groups is a good system for drug delivery due to pH-sensitive and biocompatibility may have potential applications in the fields of drug delivery,and tissue engineering.