灵芝化学成分的研究

Chemical Constituents of Ganoderma lucidum

为研究灵芝的化学成分,利用溶剂提取法,对正、反相硅胶柱层析法和半制备高效液相色谱法对其进行了分离纯化,并根据理化性质和现代波谱技术进行了结构鉴定.结果表明:从灵芝乙醇提取物分离得到的10个化合物,分别鉴定为antiquol C(1)、ganoderic acid Y(2)、7-oxo-ganoderic acid Z3(3)、7-oxo-ganoderic acid Z(4)、ganoderic acid B9(5)、ganoderic acid C2(6)、3β,7β-dihydroxy-11,15,23-trioxo-lanost-8,16-dien-26-oic acid(7)、ergosterol(8)、5α,8α-epidioxyergosta-6,22-dien-3β-ol(9)、6,9-epidioxy-ergosta-7,22-dien-3β-ol(10),其中化合物(1)为首次从该属植物中分离得到.

To study the chemical constituents of Ganoderma lucidum, the constituents were isolated and purified by the silica gel column chromatography , ODS and semi-preparative HPLC .Their structures were elucidated on the basis of chemical and spectroscopic analysis .Ten compounds were isolated from G.lucidum and identified as: antiquol C ( 1 ) , ganoderic acid Y (2), 7-oxo-ganoderic acid Z3 (3), 7-oxo-ganoderic acid Z (4), ganoderic acid B9 (5), ganoderic acid C2 (6), 3β,7β-dihydroxy-11,15,23-trioxo-lanost-8,16-dien-26-oic acid (7), ergosterol (8), 5α,8α-epidioxyergosta-6, 22-dien-3β-ol (9), 6,9-epidioxy-ergosta-7,22-dien-3β-ol (10), among them compound 1 was isolated from the genus Ganoderma for the first time.