充血性心力衰竭患者治疗前后血清甲状腺素水平的变化及临床意义

The changes and clinical significance of thyroxine in patients with congestive heart failure before and after the treatment

目的 观察充血性心力衰竭 (CHF)患者药物治疗前后血清甲状腺素含量变化 ,以探讨其临床意义。方法 用放射免疫分析法检测 36例CHF患者和 36例健康对照者的血清甲状腺素含量。结果 CHF组患者治疗前与健康对照者血清T3 、rT3 的含量间差别有显著性意义 (P <0 0 0 5 ) ,T4、TSH的含量间差别无显著性意义 (P >0 0 5 )。CHF组患者治疗前、后T3 、rT3 的均值间差别有显著性意义 (P <0 0 5 ) ,T4、TSH的均值间差别无显著性意义 (P>0 0 5 )。治疗后CHF组患者与健康对照者血清T3 、T4、TSH、rT3 的含量间差别均无显著性意义 (P >0 0 5 )。结论 甲状腺素参与了CHF发生、发展的病理过程 ,反应其严重程度 ,且随心衰的纠正而恢复正常 ,不需用甲状腺素治疗。

Objective To study the clinical significance of thyroxine in patients with congestive heart failure, we observed the change of thyroxine content before and after drug treatment.Methods To detect the content of thyroxine in pladm, radio-immunity method was used in 36 controls and 36 patients with congestive heart failure.Results There were significant differences of mean of T 3, rT 3 between pretreatment group and controls. the difference of mean of serum T 4, TSH between pretreatment and controls was no statistical significance. There were significant differences of mean of T 3, rT 3 between pretreatment and post-treatment group in CHF. The difference of mean of serum T 4, TSH between pretreatment and post-treatment group was no statistically significant. The difference of mean of serum T 3, T 4, TSH, rT 3 between post-treatment group and controls was no statistically significant.Conclusion Thyroxine played an important role in CHF pathologic process, reflected the severity of CHF and restored with the congestive heart failure recovery. However, the treatment of thyroxine was not necessary in the patients with congestive heart failure.