龟鹿补肾丸诱发排卵的临床研究

Clinical research on ovulation induction of Gui-lu Kidney-Nourishing Tablets

目的 :观察中成药龟鹿补肾丸治疗功能性无排卵患者的促排卵作用。方法 :将 6 0例功能性无排卵患者 (均属中医肾阳虚型 )随机分为两组 ,每组各 30例 ,治疗组服用龟鹿补肾丸 ,对照组服用克罗米酚、已烯雌酚、安宫黄体酮 ,B超观测排卵情况及主卵泡增长等指标。结果 :两组患者主卵泡直径明显增大 ,治疗前后比较 ,差异有显著性意义 (P <0 0 1) ;两组治疗后比较 ,差异无显著性意义 (P >0 0 5 )。治疗组观察 16 6个月经周期 ,出现排卵周期 82个 ,痊愈率达 70 % ,妊娠率达 5 6 1% ;对照组观察 175个月经周期 ,出现排卵周期 90个 ,痊愈率达 76 7% ,妊娠率达 33 3%。两组总有效率比较 ,差异无显著性意义 (P >0 0 5 ) ,但妊娠率比较 ,差异有显著性意义 (P <0 0 5 )。结论 :龟鹿补肾丸具有促进卵泡发育成熟、诱发排卵及提高妊娠率的作用。

Objective :To observe the function of Gui-lu Kidney-Nourishing Tablet,a kind of TCM,in promoting the ovulation for functional non-ovulation patients. Methods :divide 60 functional non-ovulation patients into two groups,each 30 patients.The first group takes Gui-lu Kidney-Nourishing Table(produced by Huatianbao Pharmacy).The other group is treated with clomiphene,stilbite,medroxyprogesterone acetate.The two groups are observed by B-supersonic machine to record the increase of egg follicle. Results :The first group shows noticeable changes ( P <0.01) through comparison in egg follicle′s size.The second show no significant changes ( P >0.05).After treatment of 166 periods cycle,82 cases have ovulation records.70% cured and 56.1% pregnant.The comparing group is observed 175 period cycle,90 times of ovulation is recorded,76.7% cured and 33.3% pregnant.There is no significance in comparing the effect( P >0.05)and great significance in pregnant rate. Conclusion :Gui-lu Kidncy-Nourishing Tablet can promote egg follicle maturity,helpful to enhance ovulation and pregnant rate.