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S100B蛋白与颅脑损伤的研究现状 被引量:31

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摘要 S100B蛋白是一种酸性钙结合蛋白,广泛存在于哺乳动物中枢神经系统内。生理量的S100B蛋白对神经系统的生长发育、神经细胞的增殖分化等方面具有重要影响,颅脑损伤时S100B蛋白不但高水平表达,而且溢出受损的细胞,通过受损的血脑屏障以高浓度出现于外周血清中。S100B蛋白具有神经毒性作用,在脑细胞损伤性炎症反应中扮演着重要角色。因此,检测颅脑损伤后S100B蛋白含量有助于早期预测损伤程度及预后;从分子水平阻断高浓度的S100B蛋白的神经毒性作用有望成为治疗重型颅脑损伤的一个新视窗。
出处 《国外医学(神经病学.神经外科学分册)》 2004年第3期248-251,共4页 Foreign Medical Sciences(Section On Neurology & Neurosurgery)
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