1-萘氨基甲酸酯β-环糊精手性固定相的合成及其手性分离特性

Synthesis and Enantioseparation Properties of a Novel Chiral Stationary Phase Derived from 1-Naphthylcarbamoylated β-Cyclodextrin

用1-萘基并氰酸酯修饰七叠氮基β-环糊精,生成萘氨基甲酰化的β-环糊精,将其固定在硅胶上,得到一种新的手性固定相。β-环糊精衍生物在固定相上的表面浓度为0.35μmol/m^2。用高效液相色谱测试了这种手性固定相的分离能力。结果表明新制备的手性固定相在反相条件下可用来分离手性药物。

In this work, a novel chiral stationary phase was prepared. Seven-azido-β-cyclodextrin was modified with 1-naphthyl isocyanate,and then was immobilized on aminated silica gel to produce a novel chiral stationary phase. The surface concentration of β-cyclodextrin derivative was 0.35 μmol/m^2. The enantioseparation capability of prepared chiral stationary phase was evaluated by high performance liquid chromatography. The results showed that it could separate chiral drugs in reverse phase model.