期刊文献+

支撑喉镜下CO_2激光喉部分切除最大范围的实验研究 被引量:38

Largest extension of CO_2 laser surgery for laryngeal cancer in experimental animals
下载PDF
导出
摘要 目的 通过实验动物激光手术,探索激光手术治疗声门型和声门型喉癌的安全性和手术切除范围。方法 选实验狗10只,模拟支撑喉镜下CO2激光手术,按标准的喉垂直部分或声门上水平部分切除术的切除范围,完成喉垂直部分切除7只,声门上水平部分切除3只。分别于术后立即(5只)和术后饲养40 d(5只)后麻醉状态下空气栓塞法处死。切除实验狗全喉,连续切片观察切除范围和手术后创面修复情况。结果 10只实验狗手术完成顺利,显微镜下观察满意,达到手术预期的切除范围,大体标本和连续切片观察1-5号狗喉标本,切除范围与手术一致,创面有激光烧灼后的黑色和黄褐色结痂。6-10号狗饲养40 d时处死,创面已修复。结论 动物支撑喉镜下CO2激光手术可完成经典的喉垂直部分切除术和声门上水平部分切除术的软组织切除范围,动物可存活,创面自行修复,提示扩大喉癌激光手术切除范围的可能性。 Objective To explore the security and limit resection extension of CO2 laser surgery for laryngeal cancer in experimental animal under self-retaining laryngoscope. Methods Ten experimental dogs were selected and received CO2 laser surgery with self-retaining laryngoscope. Vertical partial or supraglottic horizontal laryngectomy was performed according to the surgical criteria. All the dogs were killed immediately (5/10) or 40 days later(5/10) by using air embolus postopertively . The whole larynx was taken out, and specimens were embedded with colloidion and then serially sectioned. Dimension of excision and wound surface recovery status were observed. Results All the operations on experiment animals were successful and the results were satisfactory. The excision dimension was the same as standard surgery. Gross specimens and serial sectioning staining of 5 dogs were performed. And the other 5 dogs wound surface had already recovered. Conclusions CO2 laser surgery was comparable with traditional vertical partial laryngectomy and supraglottic horizontal laryngectomy for excision size. Animals were able to survive the surgery, wound surface could recover spontaneously . It suggested the possiblity of extended laryngectomy with laser.
出处 《中华耳鼻咽喉科杂志》 CSCD 北大核心 2004年第7期399-401,共3页 Chinese Journal of Otorhinolaryngology
关键词 支撑喉镜 C02激光 喉部分切除术 最大切除范围 实验 安全性 喉癌 Laser surgery Laryng ectomy Animal testing alternatives
  • 引文网络
  • 相关文献

参考文献8

  • 1Pradhan SA,Pai PS,Neeli SI,et al.Transoral laser surgery for early glottic cancers.Arch Otolaryngol Head Neck Surg,2003,129:623-625.
  • 2Peretti G,Piazza C,Balzanelli C,et al.Vocal outcome after endoscopic cordectomies for Tis and T1 glottic carcinomas.Ann Otol Rhinol Laryngol,2003,112:174-179.
  • 3Davis RK,Jako GJ,Hyams V J,et al.The anatomic limitations of CO2 laser cordectomy.Laryngoscope,1982,92(9 Pt 1 ):980-984.
  • 4Wolfensberger M,Dort JC.Endoscopic laser surgery for early glottic carcinoma:a clinical and experimental study.Laryngoscope,1990,100(10 Pt 1):1100-1105.
  • 5Jako GJ.Laser surgery of the vocal cords.An experimental study with carbon dioxide lasers on dogs.Laryngoscope,1972,82:2204-2216.
  • 6Krespi YP,Meltzer CJ.Laser surgery for vocal cord carcinoma involving the anterior commissure.Ann Otol Rhinol Laryngol,1989,98:105-109.
  • 7Shapshay SM,Wang Z,Rebeiz EE,et al.A combined endoscopic CO2 laser and external approach for treatment of glottic cancer involving the anterior commissure:an animal study.Laryngoscope,1996,106(3 Pt 1 ):273-279.
  • 8黄志刚,韩德民,于振坤,倪鑫,葛秀明.CO_2激光手术治疗声门型喉癌疗效分析[J].中华耳鼻咽喉科杂志,2002,37(3):219-222. 被引量:156

二级参考文献15

  • 1黄志刚,韩德民,倪鑫,葛秀明.声带癌T_1病变的CO_2激光治疗[J].耳鼻咽喉(头颈外科),1996,3(3):152-154. 被引量:26
  • 2Motta G, Espoaito E, Cassiano B, et al. T1-T2-T3 glottic tumors: fifteen years experience with CO2 laser.Acta Otolaryngol,1997, Suppl 527: 155-159.
  • 3Thomas JV, Olsen KD,Neel HB 3rd.et al.Early glottic careinoma treared with open laryngeal procedures. Arch Otolaryngol Head Neck Surg. 1994,120:264-268.
  • 4Tsunoda K, Soda Y, Tojima H, et al. Suroboscopic observation of the after radiation in patients with T1 glottic earcinoma, Acta Otolaryngol,1997, Suppl 527:165-166.
  • 5Zeitels SM. Endoscopic management of the larynx for benign and malignant disease. Adv Otularyngul Head Neck Surg,1997,11:1-36.
  • 6Moresu PR. Treatment of laryngeal carcinomas by laser endoscoptic microsurgery. Laryngoacope. 2000,110:1000-1006.
  • 7Steiner W, Results of curative Laser microsurgery of laryngeal carcinomas Am J Otolaryngol,1993,14:116-121.
  • 8Eckel HE.Thumfart WF.Laser surgery for the treatment of larynx carinomas:indications.techniques,and preliminary results.Ann Otol Rhinol Laryngol 1992,101(2 Pt 1):113-118.
  • 9Peretti G,Nieolai P, Redaelli.De Zinis LO,et al. Endoscopic CO2 laser excision for tis, T1 and T2 glottic carcinomas:cure rate and prognostic factors.Otolaryngul Head Neck Surg,2000,23(1 Pat 1) :124-131.
  • 10Shah JP, Kamel] LH, Hoffman HT, at el. Patterns of care for cancer of the larynx in the United States. Arch Otolaryngol Head Neck Surg, 1997,123 :475-483.

共引文献156

同被引文献348

引证文献38

二级引证文献330

;
使用帮助 返回顶部